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Clopidogrel is a platelet aggregation inhibitor. It works by slowing or stopping platelets from sticking to blood vessel walls or injured tissues.Reducing the risk of stroke, heart attack, or death in patients who have already had a heart attack or stroke, have other circulatory problems caused by narrowing and hardening of the arteries, or have certain other heart problems (eg, unstable angina).
Some medical conditions may interact with clopidogrel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:if you are pregnant, planning to become pregnant, or are breast-feeding, if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement,if you have allergies to medicines (eg, ticlopidine, prasugrel), foods, or other substances,if you have bone marrow disease, liver or kidney problems, blood problems, or a history of ulcers,if you have had a recent injury or surgery, including dental surgery, or if you will be having surgery.
Anticoagulants (eg, warfarin), direct thrombin inhibitors (eg, dabigatran, desirudin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen), rifamycins (eg, rifampin), rivaroxaban, salicylates (eg, aspirin), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, sertraline), or serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine, venlafaxine) because the risk of bleeding may be increased PPIs (eg, omeprazole, lansoprazole), or ticlopidine because they may decrease clopidogrel's effectiveness.