What is Bimatoprost and Timolol?

Overview

A fixed-dose mixed ophthalmic solution of Bimatoprost and timolol is used to treat high intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

It has two active ingredients: Bimatoprost, which is similar to prostamide, and Timolol, which blocks beta-adrenergic receptors.

These ingredients lower IOP and keep vision loss from happening by working together in ways that support each other.

Description

Bimatoprost (0.03%) is a man-made prostamide that makes more aqueous humour leave the eye through the trabecular meshwork and the uveoscleral paths.

Timolol (0.5%) is a non-selective beta-blocker that stops the ciliary body from making aqueous fluid.

Uses of Bimatoprost and Timolol Drops

Uses

Indications

Indicated for adult patients necessitating combined therapy to reduce excessive intraocular pressure (IOP) in:

Benefits

Controls intraocular pressure more effectively than monotherapy does.

Once-daily dose helps patients stick to their treatment regimen.

A convenient alternative to the practice of utilizing individual bottles for each medication.

Helps to lower the likelihood of glaucomatous optic nerve damage over the long run.

How Does It Work?

Through its action on prostaglandin receptors, Bimatoprost decreases intraocular pressure (IOP) by increasing the flow of aqueous humour out of the body.

Timolol inhibits beta-adrenergic receptors in the ciliary epithelium, which consequently results in a reduction in the generation of aqueous humour.

A combination of production suppression and increased drainage concludes in a reduction in intraocular pressure (IOP).

Dosage Guidelines

Direction for Use

Before application, wash your hands.

Lean your head back and slowly pull down the lower eyelid. Then, put one drop into the conjunctival sac of each reacted eye.

To lower systemic absorption, gently close your eyes and press on the corner of your eye for one to two minutes.

Do not put on any other eye medicine for at least 5 minutes.

Dosage

Single drop in the Affected eye(s), one time regualrly in the evening.

Do not use more than the suggested amount.

When Not to Use

Intolerance to Bimatoprost, Timolol, or any of the other ingredients in the medicine

Bronchial asthma or a history of having trouble breathing

Very bad chronic obstructive lung disease

Heart problems like sinus bradycardia, second or third-degree atrioventricular block, overt heart failure, or cardiogenic shock can happen.

Drug Interactions

Can Take with Other Medicine

It can be taken with other eye medicines for glaucoma, but they should be taken at least 5 minutes apart.

Talk to an eye doctor before taking this with oral beta-blockers or antihypertensives.

Other Medications to Avoid

It shouldn’t be mixed with other beta-blocker eye drops.

Be careful with digitalis, CNS depressants, and calcium channel blockers.

Do not take any more prostaglandin analogues unless your doctor tells you to.

Safety Advice

Concerns

It could irritate, May cause ocular irritation, dryness, redness, or blurred vision.

Systemic effects that could happen include slow heart rate, low blood pressure, and tiredness.

If you use it for a long time, your iris may get darker, and your eyelashes may get thicker.

Precautions

Patients with heart, lung, or kidney problems should be cautious when using this drug.

Watch for changes in the colour of your eyes and the growth of your eyelashes.

Check your vision fields and intraocular pressure often.

Warnings

If signs of intolerance show up, stop using it.

Not suggested while pregnant unless it is clearly needed.

Women who are nursing should be careful because timolol may end up in their milk.

Do not stop therapy all of a sudden without medical care.

General Instructions

What Else Can I Do to Manage Eye Pressure?

Ensure that you maintain frequent eye exams.

Follow the directions for each and every medication exactly.

Controlling your blood pressure, cholesterol, and blood sugar levels can benefit your overall health.

Activities that induce considerable increases in intraocular pressure (IOP), such as head-down yoga positions or heavy lifting, should be avoided.

Special Dietary and Lifestyle Recommendations

Eye health can be improved by eating a lot of leafy veggies, citrus fruits, and foods that are high in antioxidants and omega-3 fatty acids and drinking enough water.

Stay away from too much caffeine, booze, and salt, as they can raise your blood pressure.

Do regular low-impact tasks like swimming or walking, and spend less time in front of a screen to keep your eyes from getting tired.

Comparison with Other Treatments

Compared to Latanoprost: Both Bimatoprost and Latanoprost are prostaglandin analogues, but Bimatoprost is thought to be slightly better at lowering IOP.

However, it may be linked to more severe side effects, like hair growth and redness. Latanoprost might be easier to handle when used for a long time.

Compared to Brimonidine: Brimonidine works by lowering the production of aqueous humour and raising the flow out through the uveoscleral routes.

However, it is often linked to more allergic responses and feeling sleepy. The IOP-lowering effect of bimatoprost-timolol is stronger, and it is given less often.

What Not to Do

Do not discontinue use without consulting your physician.

Do not share the medication with others.

Do not touch the dropper tip on any surface.

Do not apply the drops more than once daily unless prescribed.

Storage Instructions

Store below 25°C (77°F) in a dry place. Do not freeze. Protect from light and moisture.

Protect from sunrays and humid.

Put it out of reach of children.

Discard the bottle four weeks after opening.