Aprepitant Capsules
| Product/Composition:- | Aprepitant Capsules |
|---|---|
| Strength:- | 80mg, 125mg |
| Form:- | Capsule |
| Packaging:- | 1 X 3 Capsules / Box |
| Therapeutic use:- | Anti Cancer |
| Package Insert/Leaflet: | Available upon request |
| Production Capacity | 10 Million Capsules/ Month |
Introduction
Aprepitant Capsules are used to prevent nausea and vomiting caused by chemotherapy. They work by blocking neurokinin, a natural substance in the brain that causes nausea and vomiting.
What is Aprepitant?
Aprepitant is an antiemetic medication. It belongs to a class of drugs known as neurokinin-1 (NK1) receptor antagonists. By blocking the action of neurokinin, it helps prevent the feeling of nausea and the act of vomiting.
Indications
Aprepitant Capsules are indicated for the prevention of:
– Acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy.
– Nausea and vomiting associated with moderately emetogenic cancer chemotherapy.
Dosage and Administration
Dosage: The recommended dosage of Aprepitant is 125 mg orally 1 hour prior to chemotherapy on Day 1, followed by 80 mg once daily in the morning on Days 2 and 3.
Administration: Aprepitant Capsules should be swallowed whole with water. They can be taken with or without food.
How Aprepitant Works?
Aprepitant works by blocking neurokinin-1 (NK1) receptors in the brain. These receptors are involved in the process that causes nausea and vomiting. By blocking these receptors, Aprepitant prevents the brain from receiving signals that trigger nausea and vomiting.
Side Effects and Precautions
Common Side Effects:
– Fatigue
– Diarrhea
– Indigestion
– Hiccups
– Loss of appetite
Serious Adverse Reactions:
– Severe allergic reactions
– Stevens-Johnson syndrome
– Liver dysfunction
Precautions:
Patients should inform their doctor about any existing liver problems or allergies. Aprepitant may interact with other medications, so a full list of current medications should be provided to the healthcare provider.
Drug Interactions
Aprepitant can interact with several medications, including:
– Warfarin
– Oral contraceptives
– Rifampin
– Ketoconazole
– Dexamethasone
Patients should provide a full list of medications to their healthcare provider to avoid adverse interactions.
Patient Information
Patients should follow these guidelines:
– Take Aprepitant exactly as prescribed.
– Report any severe side effects to the healthcare provider immediately.
– Inform the healthcare provider about all other medications being taken.
– Do not start or stop any medication without consulting the healthcare provider.
Clinical Studies
Aprepitant has been extensively studied in clinical trials. These studies demonstrate its efficacy and safety in preventing nausea and vomiting associated with chemotherapy. Aprepitant is often used in combination with other antiemetic agents to enhance its effectiveness.
Storage and Handling
Storage: Store Aprepitant Capsules at room temperature, away from moisture and heat. Keep the container tightly closed when not in use.
Handling: Only take Aprepitant as directed by a healthcare professional. Proper handling and storage of the medication are essential to ensure its efficacy.
FAQs
1. What should I do if I miss a dose?
– Take the missed dose as soon as you remember, but skip it if it’s almost time for the next dose. Do not double up to make up for the missed dose.
2. Can I take Aprepitant with other medications?
– Always consult your doctor before taking any new medications to avoid interactions.
3. What are the signs of serious side effects?
– Signs of severe allergic reactions, such as rash, itching, or swelling, and liver dysfunction symptoms should be reported immediately.
Conclusion
Aprepitant Capsules are an effective medication for preventing nausea and vomiting caused by chemotherapy. Understanding how to use them safely and effectively can help patients benefit from their protective effects while minimizing potential risks. Always follow medical advice and report any concerns to your healthcare provider promptly.