Aprepitant Capsules
| Product/Composition:- | Aprepitant Capsules |
|---|---|
| Strength:- | 80mg, 125mg |
| Form:- | Capsule |
| Packaging:- | 1 X 3 Capsules / Box |
| Therapeutic use:- | Anti Cancer |
| Package Insert/Leaflet: | Available upon request |
| Production Capacity | 10 Million Capsules/ Month |
What Are Aprepitant Capsules?
Oral drugs called aprepitant capsules assist in preventing nausea and puking, suggested during chemotherapy and surgery. They function by preventing substance P, a neurotransmitter that causes the vomiting reflex, from doing its job.
Aprepitant works on the brain’s neurokinin-1 (NK1) receptors. This differs from other antiemetics targeting serotonin (5-HT3) or dopamine receptors. It’s often used with serotonin receptor antagonists, such as ondansetron, and corticosteroids like dexamethasone for best results. This combination forms a triple therapy regimen.
Uses of Aprepitant Capsules
In particular, Aprepitant is used to stop (but not treat) nausea and puking ignited by:
Indications
Aprepitant is indicated for:
Benefits of Aprepitant
How Does Aprepitant Work?
Aprepitant works by blocking the brain’s neurokinin-1 (NK1) receptors. These receptors react to substance P. Substance P is a neurotransmitter that leads to nausea and vomiting. Aprepitant stops nausea and vomiting caused by chemotherapy.
It works in two phases: early (within 24 hours) and later (24–72 hours). This differs from other antiemetics focusing on serotonin (5-HT3) or dopamine receptors. It blocks NK1 receptors in the brain that signal nausea. This interference helps prevent vomiting.
This works well with corticosteroids, such as dexamethasone. It also pairs nicely with serotonin receptor antagonists, like ondansetron. Together, they boost overall antiemetic protection. It also helps patients recover from surgery by preventing postoperative nausea and vomiting (PONV).
Direction for Use
Dosage
The dosage of Aprepitant is contingent upon the specific condition being addressed. The standard dosage for chemotherapy-induced nausea and vomiting (CINV) in adults is 125 mg orally on Day 1, succeeded by 80 mg daily on Days 2 and 3. It is often administered one hour before chemotherapy on the initial day and in the morning on the following days.
A single 40 mg dose is provided one to three hours before anesthesia for postoperative nausea and vomiting (PONV). Aprepitant is often used with other antiemetics. These include serotonin (5-HT3) receptor antagonists and corticosteroids.
This combination boosts its effectiveness. The capsules must be ingested whole with water and taken with or without meals. People with liver issues or those consuming some particular drugs may need dosage changes.
When Not to Use Aprepitant
Aprepitant should not be used by anyone allergic to it or its ingredients. Aprepitant should not be used with pimozide. It can raise pimozide levels a lot. This may lead to serious heart issues, such as QT prolongation. People with severe liver disease should avoid Aprepitant or use it carefully because it is processed in the liver.
Children under 6 months old or weighing less than 6 kg should not use it. Its safety and effectiveness are not proven for these groups. Expecting and breastfeeding females should consult a doctor before using this medicine. Also, it should not be used to treat existing nausea and vomiting. Instead, it should be used as a preventive measure.
Can You Take Aprepitant with Other Medicines?
Yes, various antiemetic medications like the following are frequently taken with Aprepitant:
Corticosteroid dexamethasone: Increases antiemetic efficacy.
Serotonin receptor antagonists like ondansetron and palonosetron block a specific mechanism to stop nausea.
It might, however, interfere with some drugs, necessitating dose modifications or different therapies.
Interactions with Other Treatments
Aprepitant changes how liver enzymes (CYP3A4) work. This can lead to interactions with further medicines.
Raises levels of the corticosteroid dexamethasone, necessitating dose modifications. Makes oral contraceptives less effective, so consider other birth control methods. Modifies the metabolism of warfarin, which may impact blood coagulation parameters.
Other Medications to Avoid with Aprepitant
Pimozide
Strong CYP3A4 inducers such as rifampin, phenytoin, and carbamazepine
CYP3A4 inhibitors like ketoconazole and clarithromycin
Safety Advice
What Else Can I Do to Help My Condition?
Stay hydrated—Drink enough water to keep from getting dehydrated.
Eat small meals often – Avoid big foods that might make you sick.
Find your triggers – Stay away from strong smells, hot foods, and anything else that makes you feel sick.
Special Dietary and Lifestyle Recommendations
To stay healthy and lower your risk of feeling sick while taking Aprepitant, eating a varied diet and drinking plenty of water is important. Patients should stay away from alcohol and too much coffee, which can make them feel worse when they’re sick. Eating small meals more often than big ones can help keep your stomach from hurting.
Lean meats, whole grains, veggies, and other foods with lots of protein and complex carbohydrates are beneficial for you. On the other hand, you should eat less greasy, spicy, or highly processed foods. Aprepitant is used to stop people from feeling sick and throwing up.
To deal with worry, which can make them feel sick, patients should try deep breathing, meditation, or light exercise. Walking and other forms of gentle exercise may help your digestion and general health. Patients should also get enough rest and avoid strong smells or places that might make them feel sick. If you’re getting treatment, talk to a nutritionist or your doctor. This will help you stay consistent and prevent losing weight.
Comparison with Other Treatments
Better than serotonin receptor blockers at stopping delayed nausea. It is easier to handle than dopamine antagonists like metoclopramide, which can lead to movement problems. It works best when used with ondansetron and dexamethasone.
What Not to Do
Avoid taking more than the suggested quantity. Don’t stop all of a sudden without consulting a health practitioner. Don’t take it with grapefruit juice because it can change how the drug should chemically react.
Conclusion
Aprepitant is a very good medicine for stopping nausea and vomiting that can happen after surgery or treatment. It protects against acute and prolonged nausea for a long time by blocking the NK1 receptors. When used properly, it is safe and well-tolerated, but you should be aware of how it might interact with other drugs and cause side effects.