Amifostine Injections

Product/Composition:-	Amifostine Injections
Strength:-	500mg
Form:-	Injection
Production Capacity	1 Million Injection/Month
Therapeutic use:-	Anti Cancer
Package Insert/Leaflet:	Available upon request

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Introduction

Amifostine Injections are used as a cytoprotective agent in cancer treatment. They help to reduce the risk of certain side effects caused by chemotherapy and radiation therapy.

What is Amifostine?

Amifostine is a prodrug that is converted into an active free thiol metabolite. This metabolite scavenges free radicals and detoxifies reactive metabolites of cisplatin and other chemotherapy agents. It also selectively protects normal tissues without reducing the antitumor efficacy of the chemotherapy.

Indications

Amifostine Injections are indicated for:
– Reducing the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer.
– Reducing the incidence of moderate to severe xerostomia in patients undergoing postoperative radiation treatment for head and neck cancer.

Dosage and Administration

Dosage:

The recommended dose of Amifostine for renal protection is 910 mg/m², administered once daily as a 15-minute intravenous infusion, starting 30 minutes prior to chemotherapy. For radiation protection, the recommended dose is 200 mg/m², administered once daily as a 3-minute intravenous infusion, starting 15-30 minutes prior to standard fraction radiation therapy.

Administration:

Amifostine should be administered under the supervision of a healthcare professional experienced in the use of cancer chemotherapeutic agents. Patients should be well-hydrated prior to administration.

How Amifostine Works

Amifostine is converted to an active free thiol metabolite by alkaline phosphatase in normal tissues. This active metabolite acts as a scavenger of free radicals and detoxifies reactive metabolites of chemotherapy agents. It provides selective protection to normal tissues without reducing the antitumor efficacy of chemotherapy.

Side Effects and Precautions

Common Side Effects:

– Nausea
– Vomiting
– Hypotension (low blood pressure)
– Fever
– Chills
– Rash

Serious Adverse Reactions:

– Severe allergic reactions
– Hypotension requiring medical intervention
– Loss of consciousness

Precautions:

Patients should inform their doctor about any existing heart conditions, blood pressure issues, or allergies. Blood pressure should be monitored before and during infusion. Patients should remain lying down during infusion to reduce the risk of hypotension.

Drug Interactions

Amifostine can interact with several medications, including:
– Antihypertensive drugs
– Diuretics
Patients should provide a full list of medications to their healthcare provider to avoid adverse interactions.

Patient Information

Patients should follow these guidelines:
– Take Amifostine exactly as prescribed.
– Report any severe side effects to the healthcare provider immediately.
– Stay well-hydrated before and after administration.
– Remain lying down during infusion to reduce the risk of hypotension.

Clinical Studies

Amifostine has been extensively studied in clinical trials. These studies demonstrate its efficacy in reducing the cumulative renal toxicity associated with cisplatin and the incidence of xerostomia in patients undergoing radiation therapy for head and neck cancer.

Storage and Handling

Storage:

Store Amifostine at room temperature, away from moisture and heat. Keep the vials tightly closed when not in use.

Handling:

Only take Amifostine as directed by a healthcare professional. Proper handling and disposal of cytoprotective agents are essential to ensure safety.

FAQs

1. What should I do if I miss a dose?

– Contact your healthcare provider for instructions. Do not double the dose.

2. Can I take Amifostine with other medications?

– Always consult your doctor before taking any new medications to avoid interactions.

3. What are the signs of serious side effects?

– Severe fatigue, chest pain, difficulty breathing, or signs of infection should be reported immediately.

Conclusion

Amifostine Injections are an important tool in reducing the side effects of chemotherapy and radiation therapy. Understanding how to use them safely and effectively can help patients benefit from their protective effects while minimizing potential risks. Always follow medical advice and report any concerns to your healthcare provider promptly.