Sodium Chloride 0.9% And Dextrose 5% Injection

Dextrose and Sodium Chloride Injection, USP should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency, and in clinical states in which there exists edema with sodium retention. Dextrose injections with low electrolyte concentrations should not be administered simultaneously with blood through the same administration set because of the possibility of pseudoagglutination.

The intravenous administration of Dextrose and Sodium Chloride Injection, USP (dextrose and sodium chloride inj) can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states, or pulmonary edema. The risk of dilutional states is inversely proportional to the electrolyte concentrations of the injections. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injections.Excessive administration of Dextrose and Sodium Chloride Injection, USP (dextrose and sodium chloride inj) may result in significant hypokalemia.In patients with diminished renal function, administration of Dextrose and Sodium Chloride Injection, USP (dextrose and sodium chloride inj) may result in sodium retention.
5% Dextrose and 0.9% Sodium Chloride Injection, USP solution is sterile and nonpyrogenic. It is a large volume parenteral solution containing dextrose and sodium chloride in water for injection intended for intravenous administration.
Each 100 mL of 5% Dextrose and 0.9% Sodium Chloride Injection, USP contains dextrose, hydrous 5 g and sodium chloride 0.45 g in water for injection. Electrolytes per 1000 mL: sodium (Na+), 77 mEq; chloride (Cl−) 77 mEq. The osmolarity is 406 mOsmol/L (calc.), which is hypertonic. The caloric value is 170 kcal/L.