Voglibose Tablets

Product/Composition:-	Voglibose Tablets
Strength:-	0.2mg. 0.3mg
Form:-	Tablets
Production Capacity	10 Million Tablet/Month
Packaging:-	10 X 10 Tablets / Box
Therapeutic use:-	Anti Diabetic
Package Insert/Leaflet:	Available upon request

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What are Voglibose Tablets?

An alpha-glucosidase inhibitor is what Voglibose is, which is an oral diabetes medicine. People with type 2 diabetes mostly use it to control their blood sugar by lowering the spikes that happen after a meal. This medicine does not boost insulin secretion like insulin or insulin secretagogues do. Instead, it slows carbohydrate absorption from the intestines. This keeps blood sugar from dropping quickly.

Composition

Each Voglibose tablet typically contains:

Indications (Uses of Voglibose)

1. Type 2 Diabetes Mellitus – It can be treated on its own or with other diabetes medications. These include Metformin, sulfonylureas, and insulin.

2. Postprandial Hyperglycemia – Aids in regulating elevated blood glucose levels following meals.

3. Prediabetes (in Certain Instances) – To avert the advancement of prediabetes to diabetes in individuals at elevated risk.

4. Gestational Diabetes Mellitus (GDM) (Off-label Use) — It may be administered to pregnant women with diabetes, contingent upon rigorous physician oversight.

How Does Voglibose Work? (Mechanism of Action)

Beta-glucosidase is an enzyme found in the small intestine’s brush border. It breaks down complex carbs, like polysaccharides and disaccharides, into simple sugars like glucose. Voglibose stops this enzyme from doing its job. When you eat carbs, alpha-glucosidase quickly breaks them down into sugars your body can use. This makes your blood sugar go up very quickly after a meal. This medicine binds to this enzyme competitively, slowing down carbs’ breakdown and absorption.

This makes the blood sugar rise slowly and steadily instead of all at once. This method lowers post-meal hyperglycemia without directly increasing insulin production. This makes it especially helpful for people with type 2 diabetes who have trouble with blood sugar changes. Also, this medicine improves insulin sensitivity. It lowers the risk of long-term diabetes problems, like heart disease and neuropathy, by changing how glucose is absorbed.

However, because the unabsorbed carbohydrates make it to the large intestine, bacteria in the gut ferment them. This can cause side effects like gas, bloating, and slight diarrhea.

How to Take Voglibose Tablets?

When: Take it before meals, ideally right before or with the first bite of food, to keep your blood sugar from rising after a meal.

How to take it: Do not chew or crush the pill; instead, swallow it whole with water.

What to eat: While on Voglibose, eat a healthy diet for diabetics.

Dosage and Administration

Comparison with Other Anti-Diabetic Tablets

Metformin – Voglibose controls postprandial glucose, while Metformin controls both fasting & postprandial glucose.

With Acarbose – Voglibose is more potent and has fewer gastrointestinal side effects than Acarbose.

Glimepiride can lower blood sugar too much because it boosts insulin. But Voglibose does not cause hypoglycemia.

With DPP-4 Inhibitors (Sitagliptin, Vildagliptin) – The drug slows carbohydrate absorption, while DPP-4 inhibitors enhance insulin secretion.

SGLT2 inhibitors like Dapagliflozin and Empagliflozin help remove glucose through urine. Meanwhile, Voglibose lowers glucose spikes after meals.

With Insulin – Voglibose regulates post-meal sugar levels, while insulin directly lowers blood glucose by enhancing glucose uptake.

With Thiazolidinediones (Pioglitazone, Rosiglitazone) –  The drug prevents sugar spikes, while Thiazolidinediones improve insulin sensitivity.

GLP-1 Agonists (like Liraglutide and Exenatide) help manage blood sugar. They slow how glucose is absorbed. Also, they delay gastric emptying and boost insulin secretion.

Sulfonylureas (Glipizide, Glibenclamide) – This drug has a lower risk of hypoglycemia, whereas Sulfonylureas directly stimulate insulin release.

With Meglitinides (Repaglinide, Nateglinide) – Voglibose prevents sugar absorption, while Meglitinides increase insulin secretion before meals.

Other Alpha-Glucosidase Inhibitors (Acarbose, Miglitol) – This medicine is more selective and has fewer gastrointestinal side effects. 

Benefits of Voglibose

Effective control of postprandial blood sugar levels. It does not induce hypoglycemia (low blood sugar) when taken alone. It helps prevent diabetes complications by stabilizing glucose fluctuations. Weight-neutral (does not cause weight gain). It can be combined with Metformin, insulin, or sulfonylureas for enhanced control.

Safety Advice

General Instructions for Use

Follow a low-GI, high-fiber diet to reduce GI side effects. Engage in regular physical activity to improve insulin sensitivity. Monitor blood glucose levels periodically. Drink plenty of water to avoid digestive discomfort.

Warnings and Precautions

This medicine is not for following people.

Special Dietary & Lifestyle Recommendations

Increase fibre intake (vegetables, whole grains, legumes) to aid digestion. Limit refined carbohydrates (white bread, sugary snacks) to enhance Voglibose’s effectiveness. Avoid carbonated beverages and excessive dairy to reduce bloating. Engage in regular exercise like walking, yoga, or strength training.

Drug Interactions: Voglibose with Other Medications

Voglibose works well with other diabetes drugs, such as Metformin and Sulfonylureas. It doesn’t cause major side effects. However, the amount may be changed to avoid hypoglycemia or get the best glucose control.

When taken with insulin, this medicine may lower blood sugar after meals. However, it is critical to check blood sugar to prevent hypoglycemia.

Antacids that contain magnesium or aluminium may make it harder for the body to absorb Voglibose, making it less effective. This medicine should not be taken with antacids for at least two hours.

Beta-blockers, like Atenolol and Metoprolol, can hide the signs of hypoglycemia caused by this medicine. This can make it harder to tell when your blood sugar level is too low. Monitoring is a good idea.

Corticosteroids, like Prednisone, may raise blood sugar. This could reduce the effectiveness of this medicine at controlling glucose.

When taken with this medicine, ACE inhibitors like Enalapril may lead to hypotension or low blood sugar, so it is important to keep an eye on both.

Oral contraceptives may reduce this medicine’s ability to control blood sugar. But, the effect is usually small.

Ciprofloxacin and this medicine may mix. Antibiotics can change gut bacteria. They may impede the body’s ability to assimilate carbohydrates.

When NOT to Use Voglibose?

Inflammatory bowel disease and ulcerative colitis are serious digestive problems. They can lead to severe issues with the kidneys and liver. It should only be used with a doctor’s advice while pregnant or nursing. Stop using it and see a doctor if you get a rash, have trouble breathing, or have allergic reactions.

Conclusion

When used by itself, Voglibose is a good diabetes medicine that keeps blood sugar levels from rising too high after a meal. It works best for people with type 2 diabetes who have trouble with post-meal hyperglycemia. Voglibose can improve long-term diabetes care and prevent complications. It works with a healthy diet, regular exercise, and close monitoring.