Temozolomide Capsules
| Product/Composition:- | Temozolomide Capsules |
|---|---|
| Strength:- | 20mg, 100mg, 250mg |
| Form:- | Capsule |
| Packaging:- | 1 X 5 Capsules / Box |
| Therapeutic use:- | Anti Cancer |
| Package Insert/Leaflet: | Available upon request |
| Production Capacity | 10 Million Capsule/Month |
Highlights for Temozolomide
Temozolomide is considered to be oral chemotherapy that is primarily available for the treatment of brain tumours and anaplastic astrocytoma. Moreover, it serves as an alkylating agent that mainly works by interfering with the DNA of cancer cells.
The standard dose you can find is taken orally in capsule form, and the dosing is scheduled on the basis of condition.
The drug was first introduced in 1990, and the FDA gave it approval in 2005 for the treatment of glioblastoma. No doubt, it’s introduced the market to a significant approach or, we can say, advancement to treat brain cancer.
Furthermore, Temozolomide is utilized in conjunction with other therapies like as surgery and radiation. In this manner, an improvement is shown in survival rates and even quality of life.
What are Temozolomide Capsules?
Temozolomide Capsules can easily control brain tumours, including glioblastoma multiforme (GBM) and anaplastic astrocytoma. The medicine is typically taken on an outpatient basis, and this serves as an alternative to intravenous chemotherapy.
Moreover, the medicine is administered in a cycle often taken for five consecutive days, and this is followed by a break of 23 days. Temozolomide Capsule has become one of the standard parts of treatment (for GBM and other brain cancers). Hence, patients undergoing any of these difficulties now have the standard choice to get treated.
How to Use of Temozolomide Capsule
Treating Glioblastoma Multiforme:
The capsule is used for the treatment of glioblastoma multiforme, which is considered the first-line cure as the condition is defined as aggressive.
Manages Anaplastic Astrocytoma:
Prescribed for the treatment of Anaplastic Astrocytoma, which is a rare/malignant tumour.
If you are not responding to other therapies or treatments, then this drug would work for you.
Off-label use:
It has been found that Temozolomide capsules are also used for cancer or malignancy treatment.
Hence, depending upon the oncologist, the medicine is being administered.
How do I take Temozolomide Capsules?
Always take the capsule as prescribed by a doctor and not more or in less quantity. The dosage is entirely dependent upon the body weight, type of cancer, and treatment phase.
Taking the medicine at the same time each day is also preferred; hence, it should be taken care of.
It is advisable to consume the dose 1 hour before or 2 hours after a meal so that it can be consumed fast.
Must swallow the capsule with one full glass of water. Remember, do not try to crush, chew, or break anything.
You must also avoid touching the capsule if it is damaged and wash your hands thoroughly after touching it.
How Does Temozolomide Capsules Work?
Temozolomide has been defined as an anti-cancer capsule that mainly works upon damaging the DNA of cancer cells. In this manner, cancerous cell growth is prevented.
It is a pro-drug and works after its consumption and conversion takes place in MTIC.
MTIC works by adding methyl groups to specific sites on the DNA, and this mainly involves guanine bases disrupting the DNA (structure and function).
This particular damage triggers apoptosis, or programmed cell death, which effectively kills the cancer cells. Hence, Temozolomide Capsules is found to be effective against rapidly dividing cells (those in brain tumours).
The rapid absorption and short half-life decrease systemic toxicity and allow resistance in some cases due to cancer cell production.
What are the Benefits of Temozolomide Capsules?
There are some significant benefits found with Temozolomide Capsules, and below are all of those:
Potent against brain tumours:
Brain tumours like glioblastoma multiforme (GBM) and anaplastic astrocytoma can be treated with Temozolomide Capsules. They are treated in combination with radiotherapy.
Convenient to consume:
Being the first-line treatment, Temozolomide Capsules are found to be a more convenient dose than intravenous chemotherapy. In this manner, patients do not have to visit hospitals.
Cross blood-brain barrier:
This is also one of the few chemotherapy drugs capable of penetrating the blood-brain barrier, making it a suitable choice.
Treat new and Recurrent Tumors:
The capsule is also effective in managing both new and Recurrent Tumors used in cyclic therapy. This, in turn, offers evident treatment regimens tailored to individual needs.
Off-label uses:
Also explored in clinical trials and for off-label use for other cancers or conditions, expansion is possible applications.
Side Effects of Capsules
What do I Need to know Before taking Capsules?
Before you begin to consume Temozolomide Capsules, there are certain precautions or warnings associated with it, and hence consideration is needed. You must inform your doctor about other health issues related to kidneys, liver, allergies, and other infections.
Temozolomide Capsules can also harm women who are pregnant or have to feed the baby. Temozolomide has been found to impact fertility as well, both in men and women, and hence needs consideration. The medicine can further suppress your immune system, and hence, it is advisable to avoid getting in contact with sick people.
Must be aware of potential allergies; if you develop any, then immediately seek medical expert advice. You should also inform other medicines you are taking. In this manner, your doctor will let you undergo further ease.
Can I take Temozolomide Capsules if I’m pregnant?
If you are pregnant, then it is not advisable to take Temozolomide Capsules as the drug can harm the baby. Women who are accepting must consult with a doctor and make use of effective contraception during the treatment.
In this manner, complete control can be taken ahead, and also further planning for the baby can be done after a few months of recovery.
What if I take more Temozolomide Capsules than I should?
If you have taken more capsules than the acceptation, then you need to consult with a doctor to seek immediate effect immediately.
It has been found that overdosing can lead to side effects, and that could be bone marrow suppression and leads to dangerously low blood cell counts.
Hence, it is advisable to follow the prescribed dosage and not more.
What if I forget to take my Temozolomide Capsules?
By chance, if you forget to take the Temozolomide Capsules, then you can take them when you return. But remember, it should not be close to your next dose.
Be sure to take only the required amount, as if you double the dose, it can cause side effects.
Safety Advice
Patients must follow the consumption of a required amount of dosage and not more to avoid any miss-happening.
Temozolomide can also impact your blood cell counts; hence, regular monitoring of your blood is needed, and hence, consult with a doctor.
You need to avoid contact with people who have infections, and in turn, you can get treated fast.
Must also limit or even stop the intake of alcohol and other poor habits to get treated in a fast and easy manner.
Is Temozolomide a strong painkiller? Is it a narcotic?
Temozolomide is not a pain killer and should not be classified as a narcotic. However, it is a chemotherapy drug used to treat cancer, mainly brain tumours.
How should Temozolomide Capsules be stored?
The Temozolomide Capsules should be kept at room temperature. It should not be kept in moisture or heat.
Where can I Find Out More about Temozolomide Capsules?
To get more information about Temozolomide Capsules, it is advisable to consult a medical specialist to help treat them easily.