Sirolimus Tablets
| Product/Composition:- | Sirolimus Tablets |
|---|---|
| Strength:- | 1mg, 2mg |
| Form:- | Tablets |
| Production Capacity | 10 Million Tablet/Month |
| Packaging:- | 10 X 10 Tablets / Box |
| Therapeutic use:- | Nephrology |
| Package Insert/Leaflet: | Available upon request |
Introduction to Sirolimus
Sirolimus is an immunosuppressant. It helps prevent organ rejection in kidney transplant recipients. Research explores its potential to cure some cancers, autoimmune disorders, and uncommon diseases. One example is lymphangioleiomyomatosis (LAM). The medication works by calming the immune system.
So, it lowers the chance of the transplant not working. It also impacts cell growth, metabolism, and inflammation. Sirolimus was first found to be an antifungal compound. Later, it was noted for its strong immunosuppressive effects. It is widely used in transplantation medicine and experimental cancer therapies.
Composition and Strengths
Sirolimus tablets contain Sirolimus as the active ingredient. They also have excipients that help with absorption and boost stability. The medication is offered in various strengths, typically 1 mg tablets & 2 mg tablets
Inactive ingredients can change based on the manufacturer. They often include:
How to Use Sirolimus Tablets
Take Sirolimus tablets one time regularly at a fixed schedule with or without meals. Consume the whole tablet with water; do not mash, eat, or break it. Follow your doctor’s prescribed dosage strictly. If a dose is unknowingly left, try to consume it on time unless it’s time for the next dose.
Frequent blood examinations are needed to oversee drug levels. Do not take grapefruit and its juice, as they can elevate the drug concentration. Do not discontinue or adjust dosage without discussing it with a health practitioner. Tell your doctor or nurse about all of the medicines you are taking.
Mechanism of Action
Sirolimus works by blocking mTOR, which is a protein. This protein controls cell growth, division, and the immune system. It binds to FKBP-12, which is a FK506-binding protein. This creates a complex that blocks mTOR signaling.
As a result, T-cell activation and growth are hindered. This immunosuppressive effect helps prevent organ transplant rejection. Sirolimus works by suppressing the body’s immune reaction to the transplanted organ.
It also possesses antiproliferative and anti-inflammatory properties. It helps treat some cancers and prevents restenosis in coronary artery disease. Its unique mechanism separates it from calcineurin inhibitors, such as tacrolimus and cyclosporine.
Indications
Sirolimus is primarily prescribed for:
Packaging Information
Sirolimus tablets are available in various packaging formats, including: Blister packs of 10, 30, or 60 tablets. Each pack includes an information leaflet detailing dosage instructions, precautions, and storage guidelines.
What Should I Avoid While Taking Sirolimus Tablets?
While on Sirolimus, do not take these drugs or engage in these habits to prevent complications:
Before Taking This Medicine
Before beginning Sirolimus, let your physician know about:
What Other Drugs Will Affect Sirolimus Tablets?
Several drugs interact with Sirolimus, which may make it more harmful or less effective:
Before taking Sirolimus with other drugs, always get medical advice.
What Should I Know About Sirolimus Tablets Before Using It?
Before you take Sirolimus tablets, tell your doctor about any health issues. This is important if you have liver or kidney disease, infections, or a weak immune system. If you have had lung trouble or high cholesterol, tell your doctor.
Talk about any allergies you know you have because Sirolimus can cause dangerous allergic reactions. Avoid grapefruit and grapefruit juice. They can increase drug levels in your blood, leading to side effects.
While taking this medicine, you need regular blood tests to check your drug levels, kidney function, and general health. Carefully follow your doctor’s dose instructions to stay healthy.
What May Interact with This Medication?
Sirolimus can change how well and safely other medicines work when mixed. Some medicines can alter Sirolimus levels in the blood. For example, rifampin, ketoconazole, and ritonavir are a few of them.
When used together, immunosuppressants like cyclosporine may need to be taken at different doses. Some drugs for high blood pressure, cholesterol, and seizures can change how Sirolimus is absorbed.
It’s best to avoid herbal medicines, especially St. John’s Wort, because they can make it less effective. Tell your doctor about all the prescription drugs, over-the-counter meds, and supplements you use. This helps avoid harmful interactions.
Side Effects
Precautions
It is essential to check liver, kidney, and blood count function regularly. Because Sirolimus may harm the fetus, avoid getting pregnant while taking it.
Since the risk of skin cancer is higher, wearing protective clothing and applying sunscreen is important.Sirolimus can delay wound healing, so tell your doctor before you have surgery.
What Should I Know About Storage and Disposal of This Medication?
Sirolimus tablets should be kept at room temperature (20°C to 25°C) in a dry location, free from heat, moisture, and direct sunlight. Store the medication in its original container and keep it out of reach of toddlers and animals.
Humidity may impact its stability, so avoid keeping it in the bathroom or next to the kitchen sink. Unused or expired tablets should be disposed of appropriately; do not pour them down the drain or flush them down the toilet.
Follow local disposal laws or ask a pharmacist for safe disposal methods. To guarantee efficacy and safety, always verify the expiration date before usage.
Is There a Special Diet I Need to Follow While on Sirolimus Tablets?
Steer clear of high-fat meals since they inhibit the absorption of drugs. Eat more protein to promote the healing of wounds. To support kidney function, stay hydrated. Limit coffee and alcohol intake as these may affect the effects of medications.
Why Choose Sirolimus Tablets from ACTIZA Pharmaceutical PVT LTD?
Actiza Pharmaceutical PVT LTD is a leading producer of premium medications. They are known for their Sirolimus pills and other products.
Actiza Pharmaceutical PVT LTD is a trusted partner in immunosuppressive therapy. It guarantees the safety, effectiveness, and high quality of Sirolimus tablets.
Conclusion
Sirolimus tablets are key in organ transplantation. They help prevent rejection. They are also being investigated for other medical uses. Sirolimus users must follow strict medical advice, avoid interactions, and get frequent check-ups.
Choosing a trusted manufacturer like ACTIZA Pharmaceutical ensures safety and effectiveness. It also meets global regulations.