H.Pylori Kit of Rabeprazole + Clarithromycin + Tinidazol
Product/Composition:- | H.Pylori Kit of Rabeprazole + Clarithromycin + Tinidazol |
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Strength:- | 20mg + 250mg + 500mg, 20mg + 500mg + 500mg |
Form:- | Tablets |
Packaging:- | 10 X 6 Tablets / Box |
Therapeutic use:- | GIT Agent |
Package Insert/Leaflet: | Available upon request |
What is the H. Pylori Kit?
The Helicobacter pylori (H. pylori) Kit is a fixed-dose combo pack.
It treats and aids in eliminating H. pylori infections. These infections are related to chronic gastritis, MALT lymphoma, and peptic ulcer disease.
This combination treatment consists of a proton pump inhibitor (PPI) and rabeprazole sodium.
The macrolide antibiotic is Clarithromycin. Tinidazole is an antibacterial nitroimidazole.
Overview
The spiral-shaped H. pylori bacteria lives on the walls of the stomach and causes many digestive problems, such as duodenal and gastric ulcers, chronic gastritis, and even gastric carcinoma in some cases.
The H. pylori kit treats this illness by using Rabeprazole.
It’s an acid blocker that lowers stomach acid. This helps antibiotics work better.
There are two strong medicines, Clarithromycin and Tinidazole, which kill bacteria in different ways.
Description
A proton pump inhibitor (PPI) stops the H+/K+ ATPase enzyme in the belly lining, which greatly lowers gastric acid making.
This reduction in acid not only helps heal ulcers but also improves the effectiveness of antibiotics against H. pylori by creating a better pH environment.
It’s a macrolide antibiotic. A subunit of bacterial ribosomes, which stops protein synthesis and prevents bacterial growth.
It is especially effective against Helicobacter pylori and is crucial in the eradication process, particularly when used with other medications.
It is an antimicrobial from the nitroimidazole class that penetrates bacterial and protozoal cells, disrupting their DNA and causing cell death.
This has a longer half-life and is less harsh on the gut than metronidazole.
This makes it effective against anaerobic bacteria, such as H. pylori.
It also works with Clarithromycin in triple therapy.
Uses / Indications
Betterment and prevention of:
Elimination of Helicobacter pylori reaction
Duodenal ulcers
Gastric ulcers
Chronic gastritis
MALT lymphoma
Benefits
Triple treatment is very good at getting rid of H. pylori.
It helps ulcers heal more quickly and reduces pain and swelling.
It lowers the chance of getting peptic sores and gastritis again.
Make a dose schedule that is easy to follow, which improves patient adherence.
Aid in keeping problems like bleeding, perforation, or stomach cancer from happening.
Side Effects
How Does It Work?
The H. Pylori Kit uses a triple-action approach. First, Rabeprazole lowers stomach acid by blocking the proton pump.
This helps antibiotics work better and supports ulcer healing.
Clarithromycin stops bacteria from making proteins. Tinidazole harms bacterial DNA.
Together, they kill Helicobacter pylori.
This combination not only eradicates the infection but also helps relieve symptoms and prevent recurrence.
Directions for Use
Take one complete drug two times a day, preferably 30 minutes before meals.
Swallow each pill whole, along with water.
Continue the full course for 7 to 14 days, as suggested.
Even if your symptoms are better, do not skip meds or terminate treatment prematurely.
When Not to Use
Previous severe adverse reactions to any antibiotic.
Drastic hepatic impairment or active liver disease.
Past QT prolongation.
Females who are expecting a child, particularly during the embryonic stage.
Drug Interactions
Clarithromycin may interact with:
Like simvastatin and atorvastatin, they raise the chance of rhabdomyolysis.
The blood-thinning effect has grown; keep an eye on the INR.
Clarithromycin might make carbamazepine levels go up.
Tinidazole may interact with:
It may make you feel like you’re taking disulfiram, resulting in various harmful reactions.
 Elevates the chance of lithium poisoning.
Rabeprazole may reduce the absorption of:
Ketoconazole may not work as well against fungi.
 Low acidity concludes low iron uptake.
Safety Advice
General Instructions
Take the H. Pylori Kit as your healthcare provider says. Usually, you will take it twice a day before meals.
Continue eating it for the complete course, even if you initiate to get okay.
Swallow the pills whole, along with water, without crushing or chewing.
Try not to omit doses or halt the drugs midway, as it may result in incomplete eradication of the infection and the antibiotic not functioning properly.
Drink enough water and avoid alcohol while taking the course and for 72 hours after.
Also, watch for any unusual side effects like rash, severe diarrhea, or dizziness.
Discuss with the doctor as quickly as possible if these signs happen.
Special Dietary & Lifestyle Recommendations
When using the H. Pylori Kit, Consume bland, non-irritating foods to support gastric healing.
Avoid spicy, oily, and acidic items. These can irritate your gastric lining. Avoid alcohol.
It can react badly with Tinidazole and make stomach issues worse.
Eat small, recurrent foods instead of large fatty ones to ease digestion and lessens discomfort.
Eat probiotic-rich foods, such as yoghurt, to support gut health and minimize antibiotic-related side effects.
Refrain from smoking and excess caffeine, as they may delay ulcer healing and aggravate gastric irritation.
Sustaining an ideal sleep routine and controlling stress can also support recovery.
Comparison with Other Treatments
Standard Triple Therapy:
Rabeprazole + Clarithromycin + Amoxicillin – effective but not suitable for penicillin-allergic patients.
Quadruple Therapy:
PPI + Bismuth + Metronidazole + Tetracycline is a more complex treatment. It’s used when resistance is high or when previous treatments don’t work.
The Rabeprazole-Clarithromycin-Tinidazole combo:
It works well for people with penicillin allergies or those who can’t tolerate Amoxicillin.
Precautions & Warnings
Refrain from using in individuals with an existing hypersensitivity to any of the ingredients.
This must be avoided during pregnancy, particularly in the first trimester, because it contains Tinidazole.
Avoid alcohol consumption while undergoing treatment and for 72 hours following the cessation of Tinidazole.
Exercise caution in cases of hepatic impairment—ensure liver enzymes are monitored.
The risk of QT prolongation is heightened with Clarithromycin—avoid use in patients with arrhythmias.
Can It Be Taken With Other Medications?
Storage
Store in a cold, dry location, away from direct sunlight and humidity.
Maintain a temperature below 25°C (77°F).
Make sure to keep it out of reach of toddlers and animals.
Try not to utilize it after the expiration date written on the package.