Everolimus
| Product/Composition:- | Everolimus |
|---|---|
| Strength:- | 0.5mg, 0.25mg, 0.75mg, 2.5mg, 5mg, 7.5mg, 10mg |
| Form:- | Tablets |
| Production Capacity | 100000 Tablets |
| Packaging:- | 3 X 10 Tablets / Box, 6 x 10 Tablets / Box |
| Therapeutic use:- | Anti Cancer |
| Package Insert/Leaflet: | Available upon request |
About Everolimus
Everolimus, a mTOR inhibitor, regulates cell growth, proliferation, metabolism, and survival. It is commonly utilized in oncology, organ transplantation, and rare genetic illnesses. Everolimus inhibits the mTOR pathway, which cancer cells hyperactivate to grow uncontrollably. Everolimus slows tumour growth and cuts blood supply.
It also boosts hormone therapy for certain cancers. These include hormone receptor-positive, HER2-negative breast cancer, advanced renal cell carcinoma, and neuroendocrine tumours in the lung, pancreas, and gastrointestinal tract. It works by blocking this pathway.
Everolimus is a key immunosuppressant used in organ transplants. It helps prevent rejection, especially in kidney and liver transplants. Tuberous sclerosis complex (TSC) is a disease that is caused by genes. It leads to tumour growth in the brain and kidneys.
Treatment helps shrink these tumours and manage seizures. It is prescribed under medical supervision. Patients on Everolimus need regular blood tests and medical checks. This helps adjust dosages, manage side effects, and ensure safety and effectiveness.
Everolimus is a key breakthrough in precision medicine. It enhances cancer treatment, boosts transplant success, and aids in managing rare diseases. This makes it vital in today’s healthcare.
Uses of Everolimus
Medicinal Benefits
How Everolimus works
The mTOR (mammalian target of rapamycin) pathway is what Everolimus does. This pathway is very important for cell growth, metabolism, and longevity.
In cancer treatment, stopping mTOR stops the growth of the tumour and cuts off its blood supply, which slows its progress.
It stops immune cells from attacking the donated organ, which lowers the risk of rejection after an organ transplant.
How Everolimus is taken
Everolimus comes as a tablet or dispersible tablet. You take it once a day at the same time, with or without food. It must be ingested whole with a glass of water and should not be crushed, chewed, or divided. Dispersible pills need to be dissolved in water.
Follow your healthcare professional’s directions when using them for specific illnesses. Sticking to the medication plan is key to keeping drug levels steady in the body. The amount given depends on the patient’s condition, how well they respond to treatment, and any other drugs they are taking.
What happens if I miss a dose?
If you miss a dose of Everolimus, take it as soon as you remember. If it’s almost time for your next dose, though, don’t take the one you missed. Missing doses can lower treatment effectiveness.
So, it’s important to stick to your medication plan. Use reminders if you need help staying on track. Consult a physician for guidance if several doses are missed.
How long will I take Everolimus?
Cancer patients may continue its use if it is effective and well-tolerated.
Transplant recipients may require lifelong administration to avert organ rejection.
The physician will determine the precise period based on treatment efficacy and adverse effects.
Directions for Use
Ingest the pill whole—do not crush, chew, or fracture it.
When prescribed dispersible tablets, dissolve them in water prior to consumption.
Administer it concurrently each day to sustain consistent medication levels.
Routine blood tests are essential for monitoring pharmacological levels and renal function.
Storage
Maintain storage at ambient temperature (20°C-25°C), shielded from humidity and direct sunshine.
Retain in the original blister pack to safeguard against light exposure.
Store out of the reach of children and animals.
Side Effects of Everolimus
· Abnormal blood cell counts (up to 92%)
· Vomiting
· Higher cholesterol and lipid levels (up to 86%)
· Constipation
· Mouth ulcers or inflammation (up to 78%)
· Dry mouth
· Higher blood sugar levels (up to 75%)
· Weakness
· Abnormal liver labs (up to 74%)
· Change in taste
· Rash (up to 59%)
· Dizziness
· Diarrhea (up to 50%)
· Difficulty breathing
· Abnormal kidney lab values (up to 50%)
· High blood sugar
· Infections (up to 58%)
· Joint pain
· Extreme tiredness (up to 45%)
· Back pain
· Fluid buildup in the arms or legs (up to 39%)
· Difficulty sleeping
· Nail changes
· Stomach pain (36%)
· Anxiety
· Nausea (up to 32%)
· Fever (up to 31%)
· Appetite loss (up to 30%)
· Headache (up to 30%)
· Cough (up to 30%)
· Weight loss (up to 28%)
Drug-Drug Interactions Checker List:
Safety Advice
Diet & Lifestyle Advice
Healthy eating and living are vital when taking Everolimus to support overall well-being and reduce side effects. Eat a balanced diet to boost immunity and manage side effects, such as high blood sugar and cholesterol.
This contains fruits, vegetables, whole grains, and lean meats. Avoid grapefruit and grapefruit juice. They could interfere with your body’s Everolimus processing and cause negative side effects. Limit alcohol consumption because it may impair liver function and interfere with the medicine.
Since Everolimus might cause renal problems, staying hydrated is crucial. Good oral hygiene reduces the incidence of drug-induced mouth ulcers. Mild exercise like walking can help you keep a healthy weight and give you more energy. Everolimus impacts the immune system.
So, patients should stay away from sick people. They also need to keep their hands clean to prevent infections. Avoid smoking, which can reduce medicine efficacy and increase health hazards. Meditation and yoga can help reduce stress, impairing healing and immunity.
Patients should stick to their doctor’s diet and lifestyle advice. They should also go to regular checkups and immediately report any unusual symptoms.
Special Advise
Regular blood tests are needed to check kidney function, blood sugar levels, and fat profiles.
Individuals at risk of pneumonitis may require regular lung function assessments.
Patients with hepatic illness may necessitate dosage modifications.
Who might be offered Everolimus?
Patients with cancer who have seen progression following first-line therapy.
Recipients of organ transplants necessitating immunosuppressive therapy.
Patients with tuberous sclerosis need tumour reduction therapy.