Candesartan Tablets
| Product/Composition:- | Candesartan Tablets |
|---|---|
| Strength:- | 16mg |
| Form:- | Tablets |
| Production Capacity | 10 Million Tablet/Month |
| Packaging:- | 10 X 10 Tablets / Box |
| Therapeutic use:- | Cardiovascular |
| Package Insert/Leaflet: | Available upon request |
What is Candesartan?
Candesartan is a medication that is classified as an angiotensin II receptor blocker (ARB), which is a class of pharmaceuticals that are used to treat hypertension.
Its principal applications include the treatment of hypertension (high blood pressure) and heart failure.
It helps relax blood arteries by inhibiting the action of angiotensin II, which is a naturally occurring molecule. This makes it possible for blood to flow more easily and for the heart to pump more effectively.
Uses of Candesartan Tablets
Uses
Indications
Drug Interactions
Can Take With Other Medicines
Thiazide diuretics, like hydrochlorothiazide, strengthen the effects of blood pressure medicines.
Calcium Channel Blockers, like amlodipine, help keep blood pressure in check even more.
Beta-blockers, like carvedilol and metoprolol, are very helpful for people with heart failure.
Medications to Avoid or Monitor
Potassium-sparing diuretics, like spironolactone and amiloride, raise the chance of hyperkalemia.
ACE Inhibitors (like lisinopril and Enalapril): Do not use at the same time because of the risk of kidney damage and high potassium levels, especially in diabetics.
Aliskiren: People who have diabetes or kidney problems shouldn’t take it at the same time.
Lithium: This could raise lithium amounts, which could be harmful.
NSAIDs (like ibuprofen and naproxen) may not work as well and may raise the risk of kidney damage.
Benefits
Efficient in decreasing blood pressure and mitigating cardiovascular incidents.
Enhances outcomes in people with heart failure.
Alleviates stress on the heart and kidneys.
It is more well-tolerated in people with cough as a side effect of ACE medications.
Side Effects
How Does It Work?
Candesartan stops the angiotensin II type 1 (AT1) receptors from working. This stops the hormone angiotensin II from making blood vessels narrow.
Vasodilation (widening of blood vessels), less aldosterone (a hormone that keeps salt and water in the body), and lower blood pressure are all effects.
It also makes the heart work less, which is helpful for people with heart disease.
Dosage Guidelines
Direction for Use
For High Blood Pressure: Start with 8–16 mg once a day.
Dosage for maintenance: 8–32 mg daily, given all at once or spread out.
For Heart Failure: Start with 4 mg once a day.
Up to 32 mg can be taken once a day.
People who have liver disease, are older or are taking diuretics need to have their doses changed.
How to Use
As directed, take, typically, once a day. It’s okay to take with or without food.
Swallow it with a full glass of water. Every day, try to take it at the same time.
If you aren’t told to, don’t chew, crush, or split the pills.
When Not to Use
Particularly in the second and third trimesters, pregnancy may cause damage or death to the unborn child.
History of angioedema associated with prior usage of angiotensin receptor blockers (ARBs).
Bilateral renal artery stenosis.
Significant hepatic dysfunction.
Elevated potassium levels in the blood.
Safety Advice
After the first dose, Candesartan may lower blood pressure.
Blood pressure, kidney function, and salt levels must be checked regularly.
It is not a fix and must be used continuously unless told otherwise.
Regularly check your blood pressure.
Keep an eye on serum creatinine and potassium, especially in people who already have kidney problems.
Tell your doctor about whatever you use, including herbal supplements.
Avoid salt alternatives that have potassium in them.
Do not combine with aliskiren in those with renal disease or diabetes.
Risk of harm to the fetus; stop if pregnancy is found.
Patients who are low on fluids (for example, those who are taking high-dose diuretics) may have low blood pressure.
What Else Can I Do to Help My Condition?
Special Dietary & Lifestyle Recommendations
Patients using Candesartan should adopt a heart-healthy lifestyle to enhance treatment outcomes. A low-sodium diet is recommended since salt negates Candesartan’s blood pressure-lowering effects.
Cut back on canned, processed, and salty meals. Heart failure patients should drink enough water, but not too much.
Limit alcohol because it lowers blood pressure and can make you dizzy or faint. Cigarettes worsen cardiovascular disease, so quit.
Exercising at a moderate intensity for 30 minutes on most days is good for your heart and can help lower blood pressure.
Candesartan can impact kidney function and potassium levels, so people with diabetes should keep an eye on their blood glucose.
In moderation, eat potassium-rich foods like bananas, oranges, and spinach. This is important if the patient takes potassium supplements or other potassium-boosting medicines.
To get the best results with Candesartan, monitor your blood pressure at home and visit your doctor regularly.
Comparison with Other Treatments
Losartan
Comparable method of action.
Marginally reduced half-life compared to Candesartan.
It may be favored in certain individuals due to financial considerations or tolerability factors.
ACE Inhibitors (e.g., Enalapril)
Comparable efficacy in managing hypertension and heart failure.
Increased likelihood of inducing cough and angioedema.
Angiotensin receptor blockers (ARBs), such as Candesartan, are typically favored for individuals who encounter these adverse effects.
What Not to Do
Never stop taking your medication abruptly or miss a dosage.
Unless otherwise directed, do not take any potassium supplements.
For your own safety, consult your doctor before taking any combination of medications that could raise your potassium levels or alter your kidney function.
Storage Instructions
The recommended storage temperature is 15-30°C (59-86°F).
Protect from heat, light, and moisture.
Make sure children cannot get to it.
Keep out of the reach of children.