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5-Fluorouracil Injection

Product/Composition:-	5-Fluorouracil Injection
Strength:-	250mg, 500mg
Form:-	Injection
Production Capacity	1 Million Injection/Month
Therapeutic use:-	Anti Cancer
Package Insert/Leaflet:	Available upon request

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INQUIRE ABOUT 5-Fluorouracil Injection

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Overview & Description of 5-Fluorouracil Injection

5-Fluorouracil (5-FU) is an Injection that is considered a chemotherapy drug. Colorectal, breast, stomach, and pancreatic cancer are some of the cancers that it can help treat. It is a drug from the antimetabolite class. Hence, it works by hampering cancer cell DNA and RNA synthesis, preventing their growth.

A professional can administer it intravenously under medical supervision. The most common dosage is 50 mg/mL. It also stops thymidylate synthase from working, which is an enzyme needed for DNA replication. This stops cancer cells from growing.

5-FU is very helpful in oncology for treating solid tumors. Most of the time, it is used with other treatment drugs. If not, an injection is also available topically for specific skin conditions.

Uses of 5-Fluorouracil Injection

5-Fluorouracil (5-FU) Injection is used in chemotherapy treatment. It helps to deal with various cancers by halting cancer cell growth and division. It is usually used either by alone or in concert with a few other chemotherapy medications.

Common Uses:

• Colorectal Cancer: One of the most crucial treatments for advanced or metastatic colorectal cancer. In this instance, it is often used with leucovorin, oxaliplatin (FOLFOX), or irinotecan (FOLFIRI).
• Breast Cancer: This injection is for metastatic breast cancer. It is used with other therapies if previous treatments do not work.
• Gastric (Stomach) Cancer: It helps with advanced or metastatic stomach cancer. 
• Pancreatic Cancer: It is a part of combination chemotherapy that helps with advanced pancreatic cancer.
• Oesophageal Cancer: It helps shrink tumors before surgery or as a palliative treatment.
• Head and Neck Cancers: It can reduce tumor size in cancers at locations like the oral cavity, throat, and larynx.
• Cervical Cancer: It is often used in chemoradiation treatments for locally advanced cervical cancer.

Indications

5-Fluorouracil (5-FU) Injection is mainly used to manage several cancers. It helps especially those of the gastrointestinal tract, breast, and head and neck region. It is often used as an adjuvant both before and after surgery.

It helps treat tumor growth to extend survival. 5-FU is the cornerstone of chemotherapy in colorectal and gastric cancer. It works with or without other agents, e.g., leucovorin, when appropriate, sometimes with oxaliplatin.

In metastatic breast cancer as well, either alone or in conjunction when other forms of therapy are futile. It is also used for pancreatic, esophagus, and cervical cancers. The drug helps reduce tumors and improves responses to other treatments.

5-FU is a treatment to shrink tumors and increase response rates. One can use it as a sole agent or in combination therapy that works otherwise.

Benefits 

5—Fluorouracil (5-FU) Injection is a chemotherapy drug. It has many benefits for treating various cancers. It works to reduce tumor growth and increase survival rates, which is why it remains a part of many chemotherapy regimens. 5-FU is valuable because it targets rapidly dividing cancer cells. The lumps get smaller and don’t grow when you do this.

It is perfect for the treatment of gastrointestinal malignancies. These include colorectal and stomach cancer as well as breast, pancreatic, and esophagus ones. It has synergistic activity with other chemotherapy drugs when used in combinations for a higher remission rate.

Also, 5-FU is extremely important in palliative care, assisting palliation and increasing patients’ quality of life with advanced or metastatic solid tumors. As an excellent topical agent, it also has non-invasive advantages in supporting the management of related precancerous skin conditions such as actinic keratosis, superficial basal cellular carcinoma, and so on without surgery.

Mechanism of Action

5-fluorouracil (5-FU) takes the brutal way to target by restricting a cancer cell’s DNA and RNA synthesis. Thus, it stops their reproduction and is cybernetic. It can even inhibit thymidylate synthase (enzyme for DNA) synthesis, so cells get eaten.

It also triggers RNA malfunction and thus increases tumor vulnerability. This selective nature of 5-FU can be used to treat rapidly proliferating tumours such as those found in the GI tract, breast and pancreas and head/neck area.

Direction for Use

A 5-fluorouracil (5-FU) Injection is given by a healthcare professional into a vein (intravenously). The amount and timing of the dose will depend on the type of cancer, the general health status of the patient, and the patient’s treatment plans.

For example, it can be administered as a bolus or, more commonly, over hours to several days. Providers will assess kidney/liver function prior to initiating therapy to administer it safely.

Medical supervision is needed, and patients should remember to follow all medical directives and report any side effects ASAP. 5-FU is not self-administered and should only be used in an emergency clinic.

Dosage

For 5-Fluorouracil (5-FU), the amount you receive will depend on your type of cancer and general health. Here is a dosage list for different conditions:

• Colorectal Cancer: 400–600 mg/m² IV (bolus) or 225–600 mg/m² per day (infusion).
• Breast, Gastric, and Pancreatic Cancer: 500–600 mg/m² IV on days 1–5, repeated every 3–4 weeks.
• Head and Neck Cancer (with Radiation): 600 mg/m² IV once weekly or as an infusion.

Dosage may be adjusted based on organ function and side effects. Always follow a doctor’s prescription.

When Not to Use?

Patients with bone marrow depression, liver or kidney disease, or patients known to have an allergy to 5-FU should not use it. It might increase the risk for toxicity when treated with 5-fluorouracil (5-FU). It is also contraindicated in pregnancy, lactation, and those with severe infections.

It can be fatal to the fetus and suppresses the immune system. Patients with no or reduced dihydropyrimidine dehydrogenase (DPD) are not for 5-FU. As it will be more prone to severe side effects. Always have a doctor’s advice before initiating treatment.

Can you Take it with Other Medicine?

5-fluorouracil (5-FU) is frequently used in conjunction with other chemotherapy agents, including leucovorin (Ca), oxaliplatin, and irinotecan, for maximal efficacy. However, it also has the potential to interact with some medications, which will increase side effects.

Things like warfarin (blood thinner) and levels of phenytoin (anti-seizure med) develop toxicity Immunotherapies. Moreover, other chemos only further suppress the immune system. Patients must inform their doctor when taking other medications to avoid unwanted interactions.

Other Medications to Avoid

5-FU can interact with several drugs and medications that may alter the toxicity or efficacy of 5-fluorouracil (5-FU). Patients should stay away from or minimize the use of drugs:

• Blood Thinners 
• Phenytoin 
• Live Vaccines
• Immunosuppressants
• Allopurinol
• Cimetidine

Interactions with Other Treatments

5—Fluorouracil (5-FU) is a drug for chemotherapy that works in conjunction with chemotherapy drugs (leucovorin, oxaliplatin, irinotecan) and Radiation.

It is more effective but also increases toxicity.

It also increases the risk of bleeding with blood thinners and leads to phenytoin toxicity.

Live vaccines are contraindicated due to immunosuppression.

Safety Advice (Precautions, Warnings)

5-FU should be given only under medical supervision. Blood tests are required periodically to monitor the levels of these cell types and organ functions. Patients with hepatic or renal disease, bone marrow depression, or infection should exercise caution when using 5-FU, as these conditions may be aggravated by it.

Use with caution during pregnancy and breastfeeding since it can hurt the baby. People who don’t have enough dihydropyridine dehydrogenase (DPD) are more likely to get skin damage. People whose immune systems are already weak shouldn’t get live shots. Immediately go to the doctor if you suffer from persistent vomiting, diarrhea, fever, or unusual bleeding.

General Instructions

5-Fu should be administered under the supervision of the attending physician and accompanied by frequent blood tests. Take as directed, keep well hydrated, and consume a balanced diet. Avoid getting pregnant; do not breastfeed. Also, do not give live vaccines. If you are experiencing symptoms requiring other medications and/or have a fever, vomiting, or strange bleeding, report them immediately. 5– Fluorouracil (5-FU) must be given under the supervision of a doctor and should be evaluated regularly with blood tests in the clinic.

Comparison with Other Treatments