What are Gliclazide and Metformin?

Gliclazide and Metformin is an oral combination treatment with a fixed dose that is mostly utilized to treat Type 2 Diabetes Mellitus (T2DM).

Many are given this drug when there are changes to their lives, and taking only one medication is not enough to maintain their blood sugar levels.

Taking two anti-diabetic drugs that function differently can control blood sugar better than just one.

Overview

The ingredients in this medication mix are:

Gliclazide, a type of sulfonylurea, boosts insulin release from the pancreas. The typical dose is 80 mg.

Metformin hydrochloride is a biguanide. It decreases glucose manufacturing in the liver and boosts insulin sensitivity. Patients usually take it in 500 mg doses.

They function in tandem to influence various facets of glucose homeostasis.

Gliclazide works differently than metformin. While metformin lowers insulin resistance, gliclazide boosts insulin flow from active pancreatic beta cells.

Overweight patients with Type 2 diabetes often receive this dual approach. It aids them in controlling their blood sugar better.

Description

Uses / Indications

It helps adults with type 2 diabetes if diet, exercise, and treatments like metformin or sulfonylureas fail.

Facilitates the maintenance of long-term glycemic control.

Benefits

Insulin secretion and insulin resistance are both factors that are targeted by this dual mechanism of action.

Improved glycemic maintenance products lower fasting plasma glucose, postprandial glucose, and HbA1c levels.

Metformin, which is a component of the medication, may be helpful in weight control and weight loss.

This treatment is cheaper and more cost-effective than newer drugs like DPP-4 inhibitors or SGLT2 inhibitors.

A delay in progression occurs when the medication is used on a consistent basis. It slows the progression of issues associated with diabetes.

Side Effects

How Does It Work?

Makes pancreatic β-cells release more insulin.

This insulin lowers glucose by making it easier for cells to take it in and delay down the liver’s manufacturing of glucose.

Gliclazide also has reactions to blood clotting and antioxidants, which protect blood vessels.

It lessens glucose manufacturing in the liver.

It also slows sugar absorption in the intestines.

Plus, it aids the body in reacting better to insulin.

It doesn’t make insulin come out, so when utilized by itself, it lowers the chance of hypoglycemia.

Dosage Guidelines

The usual dose is 80 mg of Gliclazide and 500 mg of Metformin, taken once or twice a day with meals.

The dosage may alter based on how well the patient responds to the drug and how well they can handle it.

One shouldn’t mash or chew extended-release medications.

Always do what the doctor suggests about how much and when to take your medicine.

When Not to Use

Type 1 Diabetes Mellitus

Diabetic ketoacidosis

Severe renal impairment

Liver dysfunction

History of lactic acidosis

Expecting female or breastfeeding

Drug Interactions

Safety Advice

To lessen your chance of hypoglycemia and lactic acidosis, you should abstain from alcohol.

Consume it only if the benefits are greater than the risks. Insulin is usually preferred during pregnancy and breastfeeding.

Be careful when giving this to patients with kidney issues. Regularly notice their kidney function.

Avoid use in cases of hepatic insufficiency.

Drive or operate heavy machinery with care; hypoglycemia or weakness may occur.

General Instructions

Taking the medication with meals can lower the chance of hypoglycemia and stomach issues.

To avoid difficulties that are associated with dehydration, it is important to drink adequate water.

After you have taken this medication, you should not miss meals.

Be sure to check your blood sugar frequently, as advised by your doctor.

Lifestyle & Dietary Recommendations

To keep blood sugar levels low while using Gliclazide and Metformin, patients should follow a diabetic-friendly diet.

This diet should be less in sugars and fats but high in fiber. Good ways of fiber include whole grains, vegetables, and legumes.

To prevent hypoglycemia, eat meals regularly. This is especially important when taking sulfonylureas like Gliclazide.

Improves insulin sensitivity and aid in weight management with half an hour of moderate exercise per day.

This can be done through walking, yoga, or cycling. Managing diabetes also means drinking enough water.

It’s important to lessen stress, get enough sleep, and avoid smoking or drinking alcohol.

Comparison with Other Treatments

If monotherapy fails to control Type 2 diabetes, using Gliclazide with Metformin is a good and affordable choice.

Because of its two-pronged approach, it improves glycemic control over Metformin alone.

Modern medications like SGLT2 and DPP-4 inhibitors provide heart benefits and lower hypoglycemia risk.

This combination is a good choice for many patients. It works well, especially when resources are low.

Plus, it’s taken by mouth, making it easier to utilize than insulin.

Precautions and Warnings

Put a close eye on your kidney work and blood sugar levels. Consult your doctor before making any dosage adjustments.

If you want to be prepared for hypoglycemia, have sugar on hand, like glucose pills.

Notify all of your healthcare providers that you are taking this drug while you are in the hospital or undergoing surgery.

Observe for symptoms of lactic acidosis, such as unusual weariness, muscle soreness, or difficulty breathing.

What Else Can I Do to Help My Condition?

To improve your diabetes control, take Gliclazide and Metformin as directed.

Also, live a healthy and regular lifestyle.

Observe your blood glucose count regularly and keep note of your results to find patterns and triggers.

Attend follow-up appointments to discuss your HbA1c levels and organ function.

Stay physically active, keep a healthy weight, and get enough sleep to improve overall metabolic health.

Stress management through relaxation techniques or hobbies can also help to keep blood sugar stable.

Storage

Store in a cool, dry place.

Protect from light and moisture.

Keep out of reach of children