Sulphaguanidine Tablets

Product/Composition:-	Sulphaguanidine Tablets
Strength:-	500mg
Form:-	Tablets
Production Capacity:-	10 Million Tablet/Month
Packaging:-	10 X 10 Tablets / Box
Therapeutic use:-	Anti biotic/ Anti infective/ Anti fungal
Package Insert/Leaflet:-	Available upon request

What are Sulphaguanidine Tablets?

Sulphaguanidine is an antibacterial drug from the sulfonamide group. It is mainly used to treat bacterial infections, especially in the gastrointestinal tract. It works by stopping bacteria from growing.

This makes it helpful for infections like bacterial diarrhoea, dysentery, and other gut issues. This medicine is absorbed a little in the intestines. It thus acts quickly in the stomach without compromising the rest of the body.

Sulphaguanidine Tablets Uses

Sulphaguanidine mainly treats gastrointestinal illnesses, especially bacterial infections.

Its primary applications encompass Gastrointestinal Infections:

Bacterial Diarrhea: Indicated for the treatment of diarrhoea resulting from bacterial infections.
Dysentery (Shigellosis): Aids in diminishing the bacterial burden in instances of dysentery, marked by the presence of bloody stools.
Enteritis (Intestinal Infections): Used to treat intestinal bacterial infections often caused by E. coli, Shigella, or Salmonella species.
Prophylactic Administration in Specific Conditions: Sometimes, it is given to help people with weak immune systems who may get bacterial infections.

How Sulphaguanidine Tablets Work

These tablets stop bacteria in the digestive system from growing and multiplying, which is how they work. As a sulfonamide antibiotic, it stops bacteria from making folic acid, which bacteria need to copy their DNA to stay alive.

Sulphaguanidine stops bacteria from making folic acid by stopping the enzyme dihydropteroate synthase. This kills the bacteria in the end. Its main role is to treat bacterial infections in the intestines.

This includes bacillary dysentery and diarrhoea from easily killed organisms. Unlike systemic sulfonamides, Sulphaguanidine is not absorbed very well in the stomach.

This makes it very good at treating infections in the gut while having few effects on the rest of the body.

How should I take Sulphaguanidine Tablets?

Dosage and Administration

The standard adult dosage ranges from 500 mg to 2 g, administered 3 to 4 times daily, contingent upon the infection’s severity. The dosage for children is calibrated according to their weight and age, as a physician prescribes. The overall therapy time often spans from 5 to 10 days.

Administrative Guidelines

Ingest the pill with a complete glass of water to mitigate the likelihood of renal side effects. Administer postprandially to avert gastric irritation. Do not masticate or pulverize the pill unless instructed by a physician.

Side Effect

Nausea & Vomiting
Loss of Appetite
Mild Abdominal Pain
Diarrhea
Skin rash
Itching
Swelling
Difficulty breathing
Blood Disorders
Kidney Issues
Photosensitivity

What other drugs will affect Sulphaguanidine?

Methotrexate
Warfarin
Phenytoin
Sulfonylureas (e.g., Glipizide, Glyburide)
Cyclosporine
Digoxin
Probenecid
Antacids containing aluminium or magnesium
Rifampin
Chloramphenicol

Interactions between Sulphaguanidine Tablets and other drugs

Some drugs may interact with Sulphaguanidine, resulting in diminished efficacy or heightened toxicity. Pharmaceuticals that interact with Sulphaguanidine:

Anticoagulants (Warfarin): Elevated risk of haemorrhage.
Oral Hypoglycemics (Sulfonylureas): Augmented glycemic reduction.
Methotrexate: Elevated toxicity resulting in bone marrow suppression.
Thiazide diuretics: Increased susceptibility to allergic responses.
Antiepileptic Medications (Phenytoin): Elevated medication concentrations and toxicity.
Warning: Consistently notify your physician regarding any additional prescriptions you are utilizing.

What to avoid

Avoid extended sun exposure—utilize sunscreen and protective attire. Avoid alcohol consumption since it may exacerbate side effects.

Skip dairy products and antacids close to when you take your medicine. They can reduce how well the drug works. Limit caffeine consumption, as the medication can heighten caffeine sensitivity.

Pros and cons of Sulphaguanidine Tablets

Pros

Efficacious for intestinal bacterial infections.
Limited systemic absorption, minimizing extensive adverse effects.
Economical and readily accessible.
Functions locally within the gastrointestinal tract, diminishing overall toxicity.

Cons

Ineffective against viral infections (e.g., viral diarrhoea).
It may induce renal complications if insufficient fluids are consumed.
Potential for allergic responses in those sensitive to sulfa.
Necessitates numerous daily administrations, complicating adherence.

Expert Advice for Sulphaguanidine Tablets

Always complete the entire course to prevent bacterial resistance. Maintain hydration to avert renal problems.

Observe for adverse reactions if you possess a history of sulfa allergies. Do not provide to infants or pregnant women without medical consultation.

Diet & Lifestyle Advice

To help your body recover and reduce side effects, it is important to eat well and live a healthy life while taking Sulphaguanidine Tablets. Stay refreshed by drinking lots of water to keep your kidneys healthy and help your body get rid of drugs.

To recover gut flora, eat foods like yoghurt and fermented goods that are high in probiotics, especially if you have diarrhoea. Spicy, oily, and heavy foods can make stomach problems worse, so stay away from them.

Limit your alcohol and caffeine intake because they may mix with the medicine and make you lose water. Sulphagianidine can make you sensitive to light.

So, stay out of the sun. Use sunscreen and wear protective clothing. Get enough rest to help your body fight infection.

Also, maintain good hygiene to avoid getting sick again or spreading germs. Talk to your doctor about making more changes to your diet if the symptoms don’t go away.

What if I have taken an overdose of Sulphaguanidine Tablet

Get medical help right away if you think you’ve taken too many Sulphaguanidine Tablets. The following side effects may occur in the event of an overdose: sick stomach, vomiting, diarrhoea, lightheadedness, headache, disorientation, and skin reactions.

In severe cases, kidney disease, blood problems, and nervous system toxicity can happen.

Drink plenty of water. This helps flush the medication from your system and reduces kidney-related side effects. Always consult a healthcare professional before self-medicating or producing vomiting.

Get medical help right away if you have severe allergic reactions. This includes trouble breathing, swelling, or a bad rash.

Where should I keep my medication?

Keep it at room temperature (15 to 30°C). Stay away from water and bright sunlight.

Keep kids away from it. Do not use medicine that has to expire.