PROGYNON DEPOT (GENERIC) (ESTRADIOL VALERATE)
| Product/Composition:- | PROGYNON DEPOT (GENERIC) (ESTRADIOL VALERATE) |
|---|---|
| Form:- | Ampoule |
| Strength:- | 10mg |
| Packaging:- | 1ml |
| Therapeutic use:- | Hormones & Steroids |
| Package Insert/Leaflet: | Available upon request |
What is Progynon Depot?
Progynon Depot is given to patients in an injectable form that contains estradiol valerate, and further, it is known as the synthetic form of estrogen.
The medicine is mainly prescribed for hormone replacement therapy and also in the case of estrogen-deficient conditions. Progynon Depot was introduced in the 950s as a long-acting alternative to oral estrogen, allowing for less frequent dosing.
This injectable medicine has become one of the leading choices for various conditions like-
Helpful in treating menopause symptoms
Regulation of menstrual disorders
Prostate cancer therapy in men
Also, treating estrogen deficiency in women
Progynon Depot, no doubt, is a significant player in hormone therapy. The main reason is that it is proven for its long-lasting effect, affordability, and effectiveness.
Uses of Progynon Depot
Progynon Depot is useful in various conditions and is mentioned below-
The use of Progynon Depot has been seen in cases of women with ovarian failure or primary ovarian insufficiency.
Treating symptoms of menopause which mainly includes- hot flashes, vaginal dryness, and mood changes.
The role of Progynon Depot has also been seen in young females and those who have delayed sexual development.
Specialists advise making use of Progynon Depot to control the menstrual cycle easily.
Also useful as part of feminizing hormone therapy for transgender women.
Useful in men to reduce testosterone levels and also helps in slowing down the progression of cancer.
Indications
Used in women with low estrogen levels, and this is due to ovarian failure, hormonal imbalance, and also surgical menopause.
Menopause hormone therapy such as Progynon Depot helps to release night sweats, hot flashes, vaginal dryness, and other similar conditions.
Estrogen also helps to maintain the density of bone, and this, in turn, reduces the risk of fractures and osteoporosis after menopause.
Young girls are also suggested to use Progynon Depot with delayed puberty, and this is due to estrogen deficiency.
Benefits
Progynon Depot is found to be effective against estrogen replacement as it maintains the hormonal balance in individuals with estrogen deficiency.
Helpful in reducing menopause symptoms like hot flashes, vaginal atrophy, and even osteoporosis risk.
The injection also helps to regulate the menstrual cycle and in conditions like amenorrhea.
Suppresses the level of testosterone and slows the cancer progression.
How Does Progynon Depot Work?
Progynon Depot contains an active ingredient estradiol valerate, which is a prodrug of estradiol, and which is the primary female sex hormone.
Now, once an individual consumes it, the body metabolizes it into the active estradiol, which in turn binds to the estrogen receptors and regulates hormonal functions.
Dosage Guidelines
The dosage is different depending upon the conditions and here are the required amount of doses recommended.
For menopause symptoms, females are required to consume 10-20 mg every 4 weeks.
Transgender hormone therapy consuming 5-20 mg every 2 weeks is required.
In the case of prostate cancer treatment, 30-60 mg for every 2-4 weeks should be taken.
For delayed puberty treatment, 10 mg is recommended for 2-4 weeks.
Direction for Use
The administration is done intramuscularly and in the gluteal muscle. But it must be administered under the whole direction of an expert.
Ensure to shake the ampoule before using so that mixing can be done properly.
Do not try to self-inject it, as it requires careful consideration of the doctor’s appearance.
When Not to Use
It is advisable to avoid using Progynon Depot for different conditions like- hypertension, pregnancy, in case of liver disease, any history of blood clots, or uterine cancer.
Can Take with Other Medicine:
Progynon Depot can also be taken with other medicines, namely-
Androgen Blockers
Calcium/Vitamin D
Progestins
Other Medication to Avoid:
Some of the medicines are advisable to avoid like- Warfarin, Heparin, CYP3A4 Inducers, and also Aromatase Inhibitors.
Interactions with Other Treatments:
There are some of the interactions seen during the treatment of Progynon Depot, and these can be seen with-
Thyroid medicines where estrogen can affect the thyroid hormone level.
Diabetes medicines, where estrogen therapy can impact the blood sugar level.
Corticosteroids can also reduce the risk of fluid retention and weight gain.
Safety Advice (Concerns)
Patients have to take care while undergoing the treatment as there are chances to increase the blood clots. Hence, if you have a history of DVT, stroke, or heart disease, then care must be taken.
The condition arises when theProgynon Depot is used for the long term. Therefore, it is advisable to make use of this injection under complete supervision.
Patients are advised to keep on monitoring to ensure check-ups for blood pressure, liver function, and hormone levels.
Precautions & Warnings
The continuous and long-term use of Progynon Depot can increase breast and endometrial cancer risk.
Patients can also undergo an increased blood pressure and clotting risk.
Individuals are also advised to monitor blood glucose if diabetic.
There is a need to avoid taking the injection if you are suffering from liver disease- it can be major or mild.
General Instructions
Specialists are advised to take the required amount of dosage and under the complete supervision of a doctor.
Do not try to stop the treatment on an immediate basis without consulting with a doctor.
If you are undergoing side-effects then it is advisable to report on an immediate basis.
Moreover, the storage ofProgynon Depot is also required, and this should be in a cool place and away from moisture.
Special DietaryÂ
Lifestyle Recommendations
Patients are advised to include calcium-related food that mainly provides dairy products, and also green leafy vegetables to support easy and stable health.
Performing regular exercise so that you can maintain the body weight and reduce the risk of heart.
Ensure to avoid smoking and consuming alcohol, as it is dangerous.
Also, try to maintain complete hydration to manage the fluid pretension.
Comparison with Other Treatments        Â
Progynon Depot contains Estradiol Valerate IM, which is an injectable estrogen, and it is useful in HRT, Menopause, and Transgender Therapy. The risk factors include- Clotting risk and breast cancer risk.
The other injection is Oral Estrogen, which is available in oral form and easy to consume. The main use is HRT, Menopause. The risk involved is Higher liver metabolism impact.
Combination HRT, which mainly includes Estrogen + Progestin, is available in oral and patch forms. Its main uses are HRT for women with intact uterus and involves the risk of breast cancer and also clotting risk.
Transdermal Estrogen is the topical form, and its main uses are Menopause and osteoporosis Prevention. And comes with a Lower clotting risk.
What Not to Do
Do not try to administerProgynon Depot on your own but it has to be taken under the complete supervision of a specialist.
The medicine has to be taken in the required amount and not more.
Women should not use it during pregnancy.
Do not take it if you have any other medical underlying condition, but consult with a doctor beforehand.