What is Progesterone?

As a naturally occurring steroid hormone, progesterone is very important for controlling many bodily processes in the female reproductive system.

During pregnancy, the corpus luteum in the ovaries produces progesterone, followed by the placenta.

It is very important for getting the endometrium (the lining of the uterus) ready for implantation of a fertilized egg and keeping the pregnancy going.

It also changes how the immune system works, helps breasts grow, and keeps the effects of estrogen in check in the body.

Uses of Progesterone Vaginal Tablets

Most of the time, progesterone vaginal tablets are used in reproductive medicine, especially when:

Indications

Aid with the luteal phase in ART

Secondary lack of periods

Stopping endometrial enlargement caused by estrogen

Infertility caused by not having enough progesterone

Help during the first few months of pregnancy if you have lost other babies before

Drug Interactions

Can Take With:

Avoid or Use with Caution:

Benefits

It works locally and has fewer side effects on the whole body than oral or injectable types.

A high percentage of endometrium was reached. It helps the uterus lining get thicker and stay healthy.

ART rounds are more likely to succeed with implantation. Lessens the chance of miscarriage in women who have luteal phase problems.

Side Effects

How Does It Work?

Progesterone vaginal tablets release progesterone straight into the vaginal tissue.

This progesterone then works both locally and throughout the body to get the endometrium ready for the embryo to attach.

To help with early pregnancy, it increases changes in the endometrial lining’s secretions, stops contractions in the uterus, and changes how the immune system works.

Hormone levels are more stable when the vaginal route is used instead of the first-pass method through the liver.

Dosage Guidelines

Direction for Use:

When you touch the tablet and applicator, wash your hands first and then after.

Using the offered applicator, put the tablet deep into the vagina.

To keep hormone levels stable, take the medicine at the same time every day.

To make sure the medicine works right, don’t do things like swim or have sex right after taking it.

How to Use:

Lay on your back with your knees bent or squat down. Carefully place the device with the tablet inside it into the vagina.

To get the tablet out, press the button. Remove the applicator and clean it if it is reusable.

If told to, stay lying down for a few minutes.

When Not to Use:

Identified or presumed breast or genital malignancy. Unidentified vaginal hemorrhage.

History of thromboembolic disorders (e.g., deep vein thrombosis, pulmonary embolism). Hepatic illness or impairment.

Hypersensitivity to progesterone or any constituent of the formulation.

Safety Advice

It may change people’s moods or make them depressed if they are vulnerable. Some loss after application is normal, but it can be a pain.

It is not good for all women; each woman needs to do her risk estimate.

Talk to your doctor about your full medical background before you use it. If long-term use is needed, keep an eye on liver function.

Know the signs of thromboembolic events. ART cycles need to have regular follow-ups.

Do not use additional vaginal products. If not told to, do not use it with other female medicines.

Keep kids away from this. Stop using it and get help if you have an allergic response.

Comparison with Other Treatments

Sent straight to the uterus to provide specific support; this is especially helpful during fertility treatments.

Fewer side effects on the whole body; may cause soreness or discharge in the affected area.

It is easy to take but less efficient because it is broken down in the liver (first-pass metabolism).

It may cause adverse effects such as sleepiness, sickness, or mood instability.

Injectable progesterone (intramuscular) keeps hormone levels steady and is often used in IVF plans.

Injections that hurt and a chance of getting sores or lumps where the needle was inserted.

It is easy to use and is well absorbed locally, so it is a non-invasive choice.

It can get messy and could cause vaginal leaks or pain.

What Else Can I Do to Help My Condition?

Following your doctor’s instructions to the letter and showing up for all of your planned monitoring appointments especially during cycles of assisted reproductive treatment while taking progesterone vaginal pills will help maintain your condition.

The reproductive system as a whole and hormone balance in particular can benefit from stress reduction practices like yoga, meditation, or deep breathing.

Because of the potential negative effects on hormone function and pregnancy outcomes, it is essential that pregnant women abstain from using smoke, alcohol, and recreational drugs.

You can enhance your chances of treatment success and support hormonal balance by maintaining a healthy weight, obtaining enough sleep, and keeping physically active (as suggested by your healthcare professional).

Special Dietary & Lifestyle Recommendations

Include folate, iron, and omega-3 fatty acids in a well-rounded diet. Drink plenty of water.

Cut out inflammatory meals and processed foods. Exercising moderately is recommended unless told differently.

What Not to Do

See a doctor before self-medicating or altering your dosage.

You should not stop taking the medication abruptly or miss doses.

Unless otherwise instructed, do not insert any other items (tampons, douches, etc.).

Do not engage in sexual activity right after the insertion.

Storage Instructions

20-25°C (68-77°F) is the recommended storage temperature.

Avoid prolonged exposure to heat, wetness, and sunshine.

Keep from becoming frozen.

Make sure children cannot get to it.