Nadifloxacin Gel
| Product/Composition:- | Nadifloxacin Gel |
|---|---|
| Strength:- | 1% |
| Form:- | Gel |
| Production Capacity:- | 1 Million Gel/Month |
| Packaging:- | 10gm, 15gm |
| Therapeutic use:- | Skin Care, Dermatology |
| Package Insert/Leaflet:- | Available upon request |
Nadifloxacin Gel
Nadifloxacin inhibits the enzyme DNA gyrase that is involved in bacterial DNA synthesis and replication, thus inhibiting the bacterial multiplication. Nadifloxacin in addition to determine a therapeutic antibacterial action, can have a sebostatic and anti-inflammatory action, thus contributing to the improvement of the clinical condition of the patient.
Following a single topical application of 10 g nadifloxacin 1% cream to normal human back skin, the highest plasma concentration was determined to be 107 ng/mL with an elimination half-life of 19.4 hours. Approximately 0.09% of the administered dose was excreted in the urine over 48 hours post- dosing.
The plasma concentration reached a steady state on Day 5 of repeated administration study when nadifloxacin 1% cream was applied at 5 g twice daily to normal healthy individuals for a period of 7 days. The plasma concentration reached a peak of 4.1 ng/ml at 8 hours post-final dosing with an elimination half-life of 23.2 hours. The urinary excretion rate reached 0.16% on Day 7.