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Medroxyprogesterone Acetate Tablets

Product/Composition:- Medroxyprogesterone Acetate Tablets
Form:- Tablets
Strength:- 5mg, 10mg
Production Capacity 10 Million Tablet/Month
Therapeutic use:- Hormones & Steroids
Package Insert/Leaflet: Available upon request

What is Medroxyprogesterone?

Medroxyprogesterone is a potent synthetic hormone. It treats menstrual and hormonal disorders. It is used in hormone therapy to fix abnormal uterine bleeding. Medroxyprogesterone works by mimicking the natural hormone progesterone, helping to restore hormonal balance. It should be used under medical supervision, as improper use can lead to side effects such as weight changes, mood swings, or an increased risk of blood clots.

How Should this Medicine be Used?

Medroxyprogesterone can be taken as a pill or injected. For best results, carefully follow your doctor’s instructions when taking this medicine. They administer injections at 3- to 12-week intervals. The dosage and duration depend on the condition being treated, such as regulating menstrual cycles, managing abnormal bleeding, or as part of hormone replacement therapy. Follow the prescribed schedule carefully, typically for a few days to several weeks per cycle. Do not skip doses or stop without consulting your doctor.

How Does Medroxyprogesterone Work

This synthetic hormone disrupts the body’s chemical balance. It regulates the menstrual cycle and puts ovulation on pause. Also, this medicine can help with things like endometriosis. Thinning the uterine lining and alleviating discomfort are the mechanisms by which it functions. In hormone replacement therapy, it reduces the risk of endometrial hyperplasia. Additionally, medroxyprogesterone inhibits ovulation in higher doses, making it effective as a contraceptive. Its actions depend on the dose and treatment purpose.

How to Take Medroxyprogesterone Tablets

Various conditions require the use of medroxyprogesterone. Here’s how to take it for normal use:

  1. Follow the doctor’s instructions.
  2. Take with or without food.

Who Should Not Take Medroxyprogesterone Acetate Tablets?

If you have certain conditions, you should avoid taking medroxyprogesterone acetate tablets. When to avoid this medication:

  • Unusual vaginal bleeding
  • History of or current breast cancer
  • Stroke or heart attack
  • Blood clots or a history of blood clots
  • Liver problems
  • Allergy to medroxyprogesterone acetate or its ingredients
  • Pregnancy or suspicion of being pregnant

Other Uses for This Medicine

Medroxyprogesterone acetate is often used to assist with hormone therapy. However, it can also serve other important purposes, such as:

  • Pain from endometriosis
  • Unusual bleeding from the uterus
  • Preventing pregnancy (when injected)
  • Hormone treatment for menopause
  • Fixing menstrual cycle issues

Dosage and Administration

For Menstrual Disorders: Begin your regimen on cycle day 16 or 21. Ingest 5-10 mg daily for 5-10 days.

For Endometriosis: Consume 10 mg thrice daily for 90 days.

For Hormone Replacement Therapy: Take 5-10 mg of estrogen daily for 12-14 days.

Dosage Forms and Strengths

Medroxyprogesterone acetate comes in different forms and strengths:

  • Tablets: Usually 5 mg, 10 mg
  • Injections: 150 mg (intramuscular), 104 mg (subcutaneous)

The strength and form depend on what someone uses them for.

What should I do if I forget a dose?

Take a dose of medroxyprogesterone acetate as soon as you remember if you forget one. Continue with your usual regimen and disregard the omitted dose. Don’t double dose to catch up.

Contraindications

Do not use medroxyprogesterone acetate if you have:

  • Known or suspected pregnancy.
  • Active or a history of blood clots or stroke.
  • Unexplained abnormal vaginal bleeding.
  • Known or suspected breast or uterine cancer.
  • Allergies to medroxyprogesterone acetate or any ingredients.
  • Liver problems or dysfunction.

Warnings and Precautions

Medroxyprogesterone can lead to serious health issues. Please be cognizant of the potential hazards and adhere to the physician’s recommendations.

Warnings:

  • It might make blood clots or strokes more likely.
  • Potential links to certain types of cancer.
  • It can affect liver and kidney functions.
  • Not recommended during pregnancy.
  • Seek help for severe allergic reactions.

Your medical condition might affect how you take medroxyprogesterone. Inform your doctor about your health history.

Precautions:

  • Report heart disease to your doctor.
  • Monitor blood pressure regularly while using.
  • Consult a doctor if you have diabetes.
  • Avoid it if you have depression.
  • Inform your doctor about previous blood clots.
  • Assess liver and kidney function beforehand.

Side Effect

Common Side Effects:

Serious Side Effects:

Drug Interactions

It is very important to let your doctor know about all of your medicines. This helps to avoid interactions with medroxyprogesterone.

Medicines that may interact with medroxyprogesterone include:

  • Barbiturates
  • Bosentan
  • Carbamazepine
  • Phenytoin
  • Rifampin

Possible Adverse Reactions to this Medicine

Medroxyprogesterone may have some unwanted effects. In rare cases, serious reactions may occur, including:

  • Blood clots can cause leg pain, chest pain, or shortness of breath.
  • Difficulty breathing or swelling in the eyes and lips (severe allergic reaction).
  • Vision problems like double vision or bulging eyes.

The Following Patients may Need to be Careful when Using this Medicine

Patients should be careful when using medroxyprogesterone acetate. This includes:

  1. History of blood clots
  2. liver disease
  3. heart disease
  4. stroke

This medication isn’t suitable for pregnant women, certain cancer patients, or those with allergies to its components. Professional medical advice is crucial for safe usage.

Use In Specific Populations

Medroxyprogesterone acetate requires careful use in certain populations:

  • Pregnancy: Avoid during pregnancy, as it may harm the baby.
  • Breastfeeding: It might get into breast milk, so talk to your doctor before using it.
  • Children: Not safe or effective for children.
  • Elderly: Doses may need adjusting with age.
  • Liver or Kidney Problems: Use with caution and under medical supervision.

Precautions Before Starting Medroxyprogesterone

Before starting medroxyprogesterone, consider these important precautions:

  • Be cautious if you have heart or blood problems.
  • It might make you more likely to get breast cancer; talk to your doctor about it.
  • Conduct regular checks on bone health.
  • Exercise caution if you have liver problems or disease.

What are the Side Effects of Medroxyprogesterone?

Medroxyprogesterone tablets can cause side effects. Some common side effects include:

Interactions

Medroxyprogesterone tablets can interact with other meds. Some common interactions include:

CYP3A4 Inducers/Inhibitors:- Rifampicin and ketoconazole are drugs. They may disrupt the effectiveness of medroxyprogesterone. 

Anticoagulants:- Medroxyprogesterone may change how blood thinners work. You may need closer monitoring.

Antidiabetic Drugs:- This medicine can affect blood sugar levels, so it is important to monitor your glucose.

Related Topics on Healthify

Related topics on Healthify include:

  1. Hormone Therapy: Learn about treatments for menopause and endometriosis.
  2. Blood Clots: Understand the risks and how to prevent them.
  3. Menstrual Health: How medications affect your period.
  4. Bone Health: Tips for keeping bones strong.
  5. Mental Health: How medications can affect mood and mental health.

What Special Dietary Instructions should I follow?

To get the most out of medroxyprogesterone, following a specific diet is a good idea. 

  1. Eat balanced meals to maintain health.
  2. Limit alcohol, as it may interfere with medication.
  3. Stay hydrated to avoid dehydration and side effects.

Pros and cons of Medroxyprogesterone

Medroxyprogesterone is a medication with both benefits and potential downsides. Here’s a simple breakdown:

Pros:

  1. Regulates menstrual cycles for women with irregular periods.
  2. Treats endometriosis and uterine cancer.
  3. It can help manage hormone imbalances in various conditions.
  4. Effective for birth control.

Cons:

  1. It can cause weight gain or bloating.
  2. Could cause mood swings or sadness.
  3. Increases the risk of blood clots in some individuals.
  4. Potential impact on bone density with long-term use.

Storage

Keep Medroxyprogesterone tablets at a room temperature of 68-77°F. Stay away from kids and pets. Keep away from light and water. After the expiration date, get rid of any unused medication. Check for damage or discoloration before use and handle with dry hands.

Medroxyprogesterone Acetate Tablet Manufacturer and Supplier in India

You can find Medroxyprogesterone Acetate tablets in India at pharmacies and healthcare providers. They are available in 2.5 mg, 5 mg, and 10 mg doses. Here is a list of manufacturers:

  1. Actiza Pharmaceutical 
  2. Cipla Limited
  3. Sun Pharmaceutical Industries Ltd.
  4. Mylan Laboratories Ltd.

General information about safe and effective use of medroxyprogesterone acetate tablets

You can take medroxyprogesterone acetate tablets with food or on an empty stomach, whichever is standard for you. Follow the dosage, attend check-ups, and avoid pregnancy. It’s crucial to inform your doctor about all your medications.