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Pazopanib Hcl API

Name of Product Pazopanib Hcl
CAS No 635702‑64‑6
Therapeutic use:- Multi‑targeted receptor tyrosine kinase inhibitor – renal cell carcinoma, soft tissue sarcoma
Grade IH
Status Commercial
Form:- API Powder

Product Overview

Pazopanib Hydrochloride is an API used for the production of cancer medicines. It is a part of a class of compounds generally referred to as tyrosine kinase inhibitors, TKIs, which help impede the growth of cancer cells.

This works by preventing the formation of new kinds of blood vessels that tend to feed tumours. For this reason, it has also been described as an angiogenesis inhibitor. It targets a wide array of cell receptors such as VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and c-KIT. With these signals inhibited, the tumour has reduced capabilities for growth and dissemination. It is stable under normal conditions of manufacturing and storage; thus, it is appropriate for large-scale pharmaceutical production. Researchers are also testing PazopanibHCl in other cancers like ovarian, thyroid, and lung cancer. Because it can target several pathways, it is also studied for use with other cancer drugs.

Therapeutic Applications

Pazopanib hydrochloride is utilised in the manufacture of medications for renal cell carcinoma, a type of kidney cancer, and soft tissue sarcoma. Both diseases result in uncontrolled and speedy cell development. 

  • Renal Cell Carcinoma

In renal cancer, this API acts by blocking VEGF receptors, proteins that help blood vessels grow inside tumours. By cutting off the blood supply, the tumour growth rate diminishes and the disease becomes better controlled.

  • Soft Tissue Sarcoma

In soft tissue sarcoma, this compound prevents the spread of cancerous cells to neighbouring locations. It diminishes the nutrients that promote tumour growth and enables doctors to manage the disease during its later stages.

Specification Parameters

  • Appearance: White to off-white crystalline powder

  • Identification: Confirmed by HPLC and IR spectrum

  • Assay (on dried basis): ≥ 99.0 %

  • Water Content (Karl Fischer): ≤ 1.0 %

  • Residue on Ignition: ≤ 0.1 %

  • Heavy Metals: ≤ 10 ppm

  • Related Substances (HPLC): ≤ 0.5 % any impurity, ≤ 1.0 % total

  • Melting Range: 270–275 °C

  • Solubility: Slightly soluble in water; freely soluble in methanol, ethanol, and DMSO

Packaging & Storage

Good packaging and proper storage help protect the API and keep it stable.

  • Packaging: Packed in airtight HDPE drums or aluminium containers with double poly-bags inside. Each pack is labelled with the name, batch number, and date of manufacture.

  • Packing Sizes: The available sizes are 1 kg, 5 kg, 10 kg, and 25 kg. Custom packaging can be arranged as needed.

  • Storage: Store below 25 °C in a cool, dry place, away from sunlight and heat. 

  • Shelf Life: Up to 36 months when stored in sealed containers.

Why Choose Us

Actiza Pharma is a trustworthy producer and exporter of pharmaceutical APIs and intermediates. We are known for quality, timely supply, and strong customer support. Our Promise Includes:

  • Each batch is checked at each step to ensure purity of at least 99 %.

  • We provide DMF-ready files, validation data, and test methods to support product registration.

  • We supply small research quantities and bulk commercial lots with rapid, worldwide delivery.

  • Our facilities make use of green chemistry and energy-saving methods to minimise waste. 

  • Our technical and regulatory teams assist in every stage, from the sample stage to final shipment, for a smooth process.