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Palbociclib API

Name of Product Palbociclib
CAS No 571190‑30‑2
Therapeutic use:- CDK4/6 inhibitor – HR+, HER2– breast cancer
Grade IH
Form:- API Powder
Status Commercial
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Product Overview

Palbociclib (571190-30-2) is an active ingredient that is used to prepare the medication used in the treatment of breast cancer. It belongs to a class of drugs called CDK4/6 inhibitors. Such drugs block the enzymes controlling cell division, and therefore, cancer cells cannot develop. Once the enzymes are inactivated, cancer cells stop dividing and begin dying. Palbociclib has become one of the most important targeted agents in cancer therapy owing to its ability to slow down tumor growth and be used with hormone-based treatments.

Therapeutic Applications

Palbociclib (571190-30-2) is used for the treatment of hormone receptor-positive, HER2-negative breast cancer. They are the most common forms of adult breast cancer. Palbociclib is taken by mouth and usually with medication like letrozole or fulvestrant. Palbociclib is not like traditional chemotherapy. It targets only cancer-directed enzymes, not normal cells. That means fewer side effects and faster recovery periods between drug cycles.

For metastatic or advanced breast cancer:

  • It tends to be used to treat the disease and extend time to disease progression after chemotherapy.

  • It provides additional time of stability through inhibition of cancer cell growth.

  • Palbociclib improves the therapeutic effect when administered with hormone therapy versus administration alone.

Specification Parameters

Each batch meets cGMP and ICH Q7 guidelines. Full analytical data, including HPLC, NMR, and MS results, are supplied to confirm structure and purity.

  • CAS Number: 571190-30-2

  • Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

  • Molecular Formula: C₂₄H₂₉N₇O₂

  • Molecular Weight: 447.54 g/mol

  • Appearance: Light yellow to off-white crystalline powder

  • Solubility: Slight in water; soluble in ethanol, methanol, and DMSO

  • Purity (HPLC): ≥ 99.0 %

  • Melting Point: 265 – 270 °C

  • Loss on Drying: ≤ 1.0 %

  • Heavy Metals: ≤ 10 ppm

  • Identification Tests: IR, NMR, and MS spectra match the reference standard

Packaging & Storage

Palbociclib (571190-30-2) is adequately packaged to protect it from air, light, and moisture.

  • 1 kg, 5 kg, and 10 kg double inner liner HDPE containers.

  • Light, nitrogen-packed, and moisture-free aluminium drums.

  • Batch number, date of manufacture, and expiry date are marked on every container.

  • The product should be stored below 25 °C in a cool, dry, and well-ventilated area.

  • Protect it firmly and properly from sunlight, humidity, and heat.

  • Always handle the product with gloves and a mask for keeping the product clean and safe.

Why Choose Actiza Pharma

Actiza Pharma is a trusted company that makes and exports oncology APIs like Palbociclib. 

  • The focus is on quality, supply reliability, and customer care.

  • Made in WHO-GMP and ISO-certified, accurate plants using the modern equipment and strict checks.

  • Complete support with Drug Master Files and analytical reports for fast registration worldwide.

  • Products are shipped safely and on time through a strong logistics network.

  • Skilled staff help with formulation, validation, and documentation.

  • Uses eco-friendly and proper safe chemical processes to reduce waste and protect the overall environment.