Olaparib API

Name of Product Olaparib
CAS No 763113‑22‑0
Therapeutic use:- PARP inhibitor – for ovarian, breast, pancreatic & prostate cancers
Grade IH
Form:- API Powder
Status Regular

Product Overview

Olaparib is a chemical that prevents cancer. It is used to develop medicines for various tumors. It is a class of medicines known as PARP inhibitors. They inhibit the PARP enzyme, which repairs broken DNA within cells. When DNA cannot be repaired, cancer cells cease to reproduce and die. This, in turn, qualifies Olaparib as a brilliant or “targeted” medicine. It selectively hits cancer cells more intensely than normal cells. Since it is stable as well as pure, pharmaceutical manufacturers prefer it for predictable as well as powerful outcomes.

Therapeutic Applications

Olaparib treats cancers that are associated with defective BRCA1 or BRCA2 genes. They usually repair DNA, but if they don’t, cancers develop. Olaparib prevents this from occurring.

  • Ovarian Cancer: Administered following chemotherapy to maintain control over the disease for an extended period.

  • Breast Cancer: Is effective in patients with BRCA-related, HER2-negative breast cancer.

  • Pancreatic Cancer: Administered to patients with BRCA mutations to slow cancer progression after chemotherapy.

  • Prostate Cancer: Treats advanced prostate cancer if DNA repair genes are defective.

Physicians like Olaparib as it comes as a pill, which patients prefer over injections, and it causes milder side effects compared to older drugs. It has increased survival and quality of life for numerous patients.

Specification Parameters

  • CAS Number: 763113-22-0

  • Chemical Name: 4-[(3-[(4-Cyclopropylcarbonyl)piperazin-1-yl]carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one

  • Molecular Formula: C₂₄H₂₃FN₄O₃

  • Molecular Weight: 434.47 g

  • Appearance: White to off-white crystalline powder

  • Solubility: Slightly soluble in water; soluble in ethanol, methanol, and DMSO

  • Purity (HPLC): ≥ 99.0 %

  • Melting Point: 195 – 200 °C

  • Identification Tests: IR and NMR spectra agree with reference standards

  • Loss on Drying: ≤ 1.0 %

  • Heavy Metals: ≤ 10 ppm

Every lot adheres to international quality and safety guidelines. It’s prepared under cGMP and ICH Q7 guidelines. Reports for analysis, such as HPLC, IR, and NMR, are provided for assurance of purity as well as structure.

Packaging & Storage

Olaparib API is packed safely to keep it dry and clean. Store it below 25°C, in a cool and dry place. Keep away from direct light and damp air. Always wear gloves and protective clothing while handling. It usually comes in:

  • 1 kg, 5 kg, or 10 kg HDPE packaging with inner liners.

  • Bags of aluminium foil for protection from moisture.

  • Sealed drums for bulk purchases with nitrogen fill for added security.

Why Choose Actiza Pharma

Actiza Pharmaceuticals provides reliable and high-quality API production. It produces Olaparib and other oncology APIs under strict quality and safety regimes.

  • Certified Quality: Actiza’s plants are WHO-GMP and ISO certified, which provides high purity as well as safety.

  • Regulatory Support: It provides full technical files and DMFs to help with global drug approval.

  • Purity Tested: We check and document each production stage to meet pharmacopeial standards.

  • On-Time Delivery: Actiza has a solid global supply network. It delivers orders safely and quickly.

  • Technological Support: Clients receive complete assistance for formulation and testing while formulating finished products. 

  • Green Manufacturing: Actiza employs environmentally-friendly processes as well as waste-reduction techniques to ensure the safety and sustainability of production.