Canagliflozin API
| Name of Product | Canagliflozin API |
|---|---|
| CAS No | 842133‑18‑0 |
| Therapeutic use:- | SGLT2 inhibitor for type 2 diabetes |
| Grade | IH |
| Form:- | API Powder |
| Status | Commercial |
Product Overview
Canagliflozin is an active pharmaceutical ingredient (API) that falls within the category of SGLT2 inhibitors. It is used mainly in the manufacturing and research of type 2 diabetes. Its CAS number is 842133-18-0. Its chemical formula is C24H25FO5S, and its molecular weight is 444.5 g/mol.
The substance is a white or off-white crystalline powder. It is not easily soluble in water. It disperses more readily in organic solvents like ethanol, methanol, and DMSO. It is stable under dry, cool conditions. It may degrade when it is subjected to moisture, light, or heat.
Canagliflozin works by blocking the SGLT2 transporter in the kidneys. It does not permit glucose reuptake back into the blood. The glucose is released in urine instead. This reduces the blood sugar level. The process is insulin-independent, hence dissimilar from currently available diabetes drugs.
Each batch of Canagliflozin is produced under Good Manufacturing Practice (cGMP). It is provided with a certificate of analysis (COA), stability information, and an impurity profile. Each step of manufacturing follows rigorous quality parameters in an effort to meet international standards.Â
Therapeutic Applications
Canagliflozin is used in the management of type 2 diabetes. Inhibiting SGLT2 in kidney tubules decreases the amount of blood glucose. Since the mechanism is insulin-independent, it works even in patients with defective insulin action.
The drug has also shown other advantages in studies. It can reduce the risk of cardiovascular events in some patients. It will also protect kidney function in diabetics with diabetic nephropathy. Because of these results, Canagliflozin is considered more than a blood sugar drug. It guards the heart and kidneys.
Specification Parameters
Canagliflozin is tested to determine purity, identity, and safety. Typical specifications are:
Packaging & Storage
Standard packaging is in a 25 kg fiber drum with double liner inner packing. Pilot usage packs of 1 to 5 kg are also available. All packs are sealed, tamper-resistant, and batch-coded with full batch details.
Recommended storage conditions are 15–25 °C, dry, and not in direct sunlight. Keep away from strong heat, moisture, or oxidizing agents. When stored correctly, the product will remain stable for 36 months.
For handling, the workers must wear gloves, protective apparel, and safety goggles. The generation of dust is to be avoided by working within local exhaust systems. Waste disposal should be done in line with accepted environmental guidelines.
Why Choose Us
Actiza provides Canagliflozin with a keen focus on quality and regulatory compliance. Our drug is manufactured in world-class cGMP facilities using validated procedures.
Every batch is released only after passing all analytical tests. We offer complete documentation support, including COA, MSDS, stability studies, and impurity testing.
Drug Master Files (DMF) and elemental impurity assessments are offered as regulatory support.
Customization is possible. Clients are free to order micronized particle size, special controls for impurities, or custom packaging. Our team ensures a hassle-free method transfer and compliance with USP, EP, and JP standards.
Our supply chain is robust. We have qualified suppliers on board, keep safety stock, and possess backup sources for raw material. This ensures timely delivery and smooth supply.