2,3-Dichloro Benzoyl Cyanide
| Name of Product | 2,3-Dichloro Benzoyl Cyanide |
|---|---|
| CAS No | 77668-42-9 |
| Therapeutic use:- | Anti-epileptic |
| API Name | Japan, koser, Ching, Lamotrigine |
| Form:- | API Powder |
| Status | Regular |
Product Overview
2,3-Dichlorobenzoyl cyanide, also written 2,3-dichlorobenzoyl nitrile or (2,3-dichlorophenyl)oxoacetonitrile, is a yellow crystalline solid supplied under CAS 77668-42-9.
Structurally it is an acyl cyanide a carbonyl group bonded directly to a nitrile carbon on a 2,3-dichlorinated benzene ring.
That arrangement gives it exactly the reactivity its downstream use requires.
The carbonyl is strongly electrophilic and the cyanide is an excellent leaving group, so the molecule presents two adjacent electrophilic carbons in a defined geometry.
Condense it with a bifunctional nitrogen nucleophile and a heterocyclic ring closes across both.
That is precisely what happens in the manufacture of lamotrigine.
The acyl cyanide is condensed with aminoguanidine, and the resulting adduct is cyclised to give 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine lamotrigine, a first-line antiepileptic and bipolar maintenance medicine on the WHO Model List of Essential Medicines.
The same reactivity that makes it useful makes it demanding.
Acyl cyanides hydrolyse readily, and hydrolysis of this compound releases hydrogen cyanide.
Strict moisture exclusion has to continue through drying, packing, storage and the customer’s charging step. Water is not a quality nuisance here. It is the hazard.
Grades and specifications are available on request.
Actiza has over 12 years of B2B pharmaceutical export experience, 500+ global clients and a supply footprint across 40+ countries, backed by WHO-GMP and ISO-certified group manufacturing infrastructure in Gujarat, India.
Key Highlights
Certificate of Analysis and GHS-format Safety Data Sheet with every batch.
12+ years of export experience across 40+ countries.
Application in Synthesis
This intermediate has one dominant commercial destination, and the route is short.
Lamotrigine is used in the treatment of epilepsy and in bipolar maintenance therapy, and appears on the WHO Model List of Essential Medicines.
Demand is broad, geographically distributed and structurally stable a materially better commercial position than an intermediate tied to a niche or withdrawn product.
Applications at a Glance
| Application | Role | Notes |
|---|---|---|
| Lamotrigine manufacture | Key starting material supplying both the dichlorophenyl group and the two ring carbons of the triazine | The dominant commercial application |
| Lamotrigine impurity reference standard | Qualified reference material for a specified impurity | Used in analytical method development, method validation and ANDA filings |
| Triazine and heterocycle chemistry | Bis-electrophile for ring construction with bifunctional nitrogen nucleophiles | Research and development-scale use |
Industry Segments Served
Lamotrigine API manufacturers.
CDMOs and contract synthesis organisations executing client-owned routes.
Analytical and QC laboratories supporting ANDA and generic filings.
Cyanide Safety, Moisture and Emergency Preparedness
Why Moisture Is the Hazard, Not Just a Specification
Acyl cyanides hydrolyse. When this compound meets water it breaks down to 2,3-dichlorobenzoic acid and hydrogen cyanide.
In a sealed drum with a low-moisture specification and an inert blanket, that reaction does not meaningfully proceed.
In a drum that has taken up atmospheric moisture, in a humid transfer area, or in a waste stream that has been acidified, it does.
Handling Rules
Keep containers sealed under a dry inert blanket; minimise open-container time and re-seal immediately after dispensing.
Handle in a closed system or under effective local exhaust ventilation, with HCN detection appropriate to the operation.
Allow containers to reach ambient temperature before opening to prevent condensation on the solid.
Charge into thoroughly anhydrous systems; water in the reaction solvent generates HCN in the vessel.
Never acidify cyanide-bearing waste streams; treat cyanide waste through a validated destruction route before it reaches effluent.
Segregate strictly from water, acids, alcohols, amines and strong bases.
Full chemical-resistant PPE the compound is toxic by skin contact as well as by ingestion and inhalation.
Ensure cyanide-specific first aid provision, trained responders and emergency procedures are in place before the material arrives on site.
Note the aquatic hazard classification plan containment so that no cyanide-bearing material can reach drains or watercourses.
What We Do Before You Receive It
Handling, storage and emergency documentation issued ahead of the first shipment, not with it.
Retest guidance for any consignment that shows evidence of moisture ingress or seal compromise in transit.
Technical Specifications
The parameters below represent our standard commercial specification. Customer-specific specifications can be agreed at enquiry stage.
| Parameter | Specification |
|---|---|
| Chemical Name (IUPAC) | 2-(2,3-Dichlorophenyl)-2-oxoacetonitrile |
| Common Synonyms | 2,3-Dichlorobenzoyl cyanide; 2,3-Dichlorobenzoyl nitrile; (2,3-Dichlorophenyl)oxoacetonitrile; 2,3-Dichloro-α-oxobenzeneacetonitrile |
| CAS Number | 77668-42-9 |
| MDL Number | MFCD00792559 |
| EC / EINECS Number | Available on request |
| Molecular Formula | C₈H₃Cl₂NO |
| Molecular Weight | 200.02 g/mol |
| Appearance | Yellow to pale yellow crystalline solid |
| Assay / Purity | Available on request |
| Identification | IR and ¹H-NMR conform to reference standard |
| Melting Point | Available on request |
| Stage of Synthesis | Key starting material |
| Downstream API | Lamotrigine |
| Residual Copper | Available on request |
| Isomeric Dichlorobenzoyl Cyanides | Available on request |
| 2,3-Dichlorobenzoic Acid | Available on request |
| Water Content (Karl Fischer) | Available on request |
| Other Related Substances | Individual and total limits as per in-house standard; reported on COA |
| Residual Solvents | As per ICH Q3C |
| Elemental Impurities | Per ICH Q3D elemental impurity statement |
| Solubility | Soluble in DMSO, acetonitrile and aromatic hydrocarbons; reacts with water, alcohols and amines |
| Storage Condition | Store cool and dry in tightly closed original packing under inert blanket, away from water, acids, alcohols, amines and bases |
| Shelf Life | As stated on the batch COA, in unopened original packing under recommended storage |
| GHS Classification | Available on request |
| Transport Classification | Available on request |
Regulatory & Documentation Support
This is a starting material, so a DMF or CEP does not apply to it as a standalone item.
What buyers need is a well-characterised material with documentation supporting their manufacturing filing, their elemental impurity assessment and their impurity control strategy.
Documentation Supplied
Certificate of Analysis- batch-specific.
Safety Data Sheet in GHS format, with destination-language versions on request.
Cyanide-specific handling, storage and emergency guidance, issued ahead of first delivery.
Technical Data Package- manufacturing flow, analytical methods, specification rationale, impurity profile.
GMP Starting Material declaration under ICH Q7 principles, where the GMP grade is ordered.
ICH Q3D elemental impurity statement.
ICH Q3C residual solvent statement.
Certificate of Origin, Non-GMO declaration, BSE/TSE-free and allergen statements.
Dangerous goods declaration and compliant marking and labelling.
Site audit access, subject to prior scheduling and confidentiality agreement.
Packaging, MOQ & Logistics
| Parameter | Details |
|---|---|
| Standard Packing | Sealed, inert-blanketed, moisture-barrier containers in UN-approved outer packaging appropriate to an acutely toxic solid |
| Pack Sizes | Available on request |
| Minimum Order Quantity | Available on request |
| Production Lead Time | Available on request |
| Monthly Capacity | Available on request |
| Sampling | Sample supply requires full dangerous-goods handling and confirmation of cyanide-appropriate handling capability at the receiving site |
| Shipping Terms | FOB / CIF / CFR / EXW, as agreed |
| Mode of Transport | Sea freight in UN-approved packaging; air freight availability available on request |
| Temperature Management | The material is a low-melting solid; season- and destination-appropriate temperature control is applied |
| Port of Loading | Available on request |
| Dangerous Goods | Acutely toxic solid- UN number, packing group and IMDG segregation per your own classification |
| Environmental | Aquatic hazard classification requires containment planning in storage and in transit |
| Export Documentation | Standard commercial plus full DG documentation |
Why Choose Us as Your Supplier
Batch-to-Batch Consistency
Every batch released against the same analytical protocol with retained samples held for the declared shelf-life.
Where a customer qualifies our material into a validated route, we notify any change that could affect the impurity profile before it reaches their site.
Export & Client Support
With 12+ years of B2B pharmaceutical export experience, 500+ global clients and shipments across Asia, Africa, Latin America, the CIS region and the Middle East, our commercial and documentation teams work across time zones and understand hazardous cargo requirements.
Frequently Asked Questions
What is this intermediate used to make?
Lamotrigine. The acyl cyanide is condensed with aminoguanidine and the adduct is cyclised to give 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine.
The compound supplies both the dichlorophenyl group and two of the triazine ring carbons.
Lamotrigine is used in epilepsy and in bipolar maintenance therapy and appears on the WHO Model List of Essential Medicines.
How hazardous is it?
This is an acutely toxic, cyanide-releasing material.
Consult the Safety Data Sheet supplied with your batch for the classification, and ensure cyanide-appropriate detection, PPE, emergency provision and waste treatment are in place before the material arrives.
Why does moisture matter so much?
Because for this compound moisture control is a safety measure as much as a quality one.
Water hydrolyses the acyl cyanide to 2,3-dichlorobenzoic acid and hydrogen cyanide.
Moisture in incoming material therefore means lower active assay, an acid impurity already present, and HCN generated inside the drum. We control water by Karl Fischer and ship under a sealed inert blanket.
What is the Minimum Order Quantity?
Our minimum order quantity is available on request.
Dangerous-goods packaging and documentation costs make very small consignments uneconomic for both parties, so smaller quantities are discussed at enquiry stage.
Request a Quote
Tell us the grade, quantity and destination, and our team will respond with pricing, lead time, the documentation set and the handling requirements for 2,3-Dichlorobenzoyl Cyanide (CAS 77668-42-9).