1-(6-Methylpyridin-3-YI)-2-[4-(Methyl sulfonyl) Phenyl]ethenone [Ketosulfone Both Routes]
| Name of Product | 1-(6-Methylpyridin-3-YI)-2-[4-(Methyl sulfonyl) Phenyl]ethenone [Ketosulfone Both Routes] |
|---|---|
| CAS No | 221615-75-4 |
| Therapeutic use:- | NSAID |
| API Name | Etoricoxib |
| Form:- | API Powder |
| Status | Commercial |
Product Overview
1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, known throughout the industry simply as the etoricoxib ketosulphone, is supplied under CAS 221615-75-4 with the molecular formula C₁₅H₁₅NO₃S and a molecular weight of 289.35.
It is a deceptively simple molecule: a methyl ketone bridging two aromatic rings, with a 6-methylpyridine on one side and a 4-methylsulfonylphenyl group on the other.
Both of those rings appear unchanged in etoricoxib, and the single methylene between them becomes part of the central pyridine ring of the finished drug.
The compound was first disclosed as a novel intermediate in the late 1990s and has been the subject of considerable process development since, because it sits at a central step of the etoricoxib route.
Grades and specifications are available on request. Every consignment carries a batch Certificate of Analysis and a GHS-format Safety Data Sheet.
Actiza Pharmaceutical Pvt. Ltd. has over 12 years of B2B pharmaceutical export experience, 500+ global clients and a supply footprint across 40+ countries, backed by WHO-GMP and ISO-certified group manufacturing infrastructure in Gujarat, India.
Key Highlights
Certificate of Analysis and GHS-format Safety Data Sheet with every batch.
12+ years of export experience across 40+ countries.
Application in Synthesis
The Final Step
The ketosulphone is cyclised with a three-carbon reagent to close the second pyridine ring and give etoricoxib, 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-2,3′-bipyridine.
The methylene carbon of the ketosulphone and its two flanking positions become part of the new ring.
Everything else in the molecule is already in place at this stage.
That is why buying at this point removes so much: the methylsulfonyl group is already installed and at the correct oxidation state, the pyridine methyl is already positioned, and the carbon skeleton is complete.
Applications at a Glance
| Application | Role | Notes |
|---|---|---|
| Etoricoxib manufacture | Penultimate-stage intermediate; cyclisation gives the API directly | The dominant commercial application; etoricoxib has been marketed as Arcoxia since 2002 |
| Diarylpyridine COX-2 inhibitor chemistry | Bis-aryl ketone building block for pyridine ring construction | Referenced in the broader COX-2 inhibitor patent literature |
Industry Segments Served
Etoricoxib API manufacturers.
CDMOs and contract synthesis organisations executing client-owned routes.
Impurity and reference standard suppliers.
Analytical and QC laboratories supporting generic filings.
Technical Specifications
The parameters below represent our standard commercial specification. Customer-specific specifications can be agreed at enquiry stage.
| Parameter | Specification |
|---|---|
| Chemical Name (IUPAC) | 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone |
| Common Names | Etoricoxib ketosulphone; ketosulphone intermediate; 1-(6-methylpyridin-3-yl)-2-[4-(methylsulphonyl)phenyl]ethanone |
| CAS Number | 221615-75-4 |
| Molecular Formula | C₁₅H₁₅NO₃S |
| Molecular Weight | 289.35 g/mol |
| MDL / EC Number | Available on request |
| Appearance | Available on request |
| Assay / Purity | Available on request |
| Identification | IR and ¹H-NMR conform to reference standard |
| Melting Range | Available on request |
| Stage of Synthesis | Penultimate-stage intermediate |
| Downstream API | Etoricoxib |
| Other Related Substances | Individual and total limits as per in-house standard; reported on COA |
| Water Content (Karl Fischer) | Available on request |
| Residual Solvents | As per ICH Q3C |
| Elemental Impurities | Per ICH Q3D elemental impurity statement |
| Solubility | Available on request |
| Storage Condition | Store cool and dry in tightly closed original packing, protected from moisture and light |
| Shelf Life | As stated on the batch COA, in unopened original packing under recommended storage |
| GHS Classification | Available on request |
| Transport Classification | Available on request |
Handling & Storage Guidance
This is a stable crystalline organic solid with no significant reactivity hazard. The guidance below is about preserving specification.
Store cool and dry in tightly closed containers, protected from moisture and light.
Allow containers to reach room temperature before opening to prevent condensation.
Minimise open-container time and re-seal immediately after dispensing.
Note that the methylene between the carbonyl and the aryl ring is activated, so the compound has an accessible enol form keep it away from strong base during storage.
Keep away from strong oxidising agents and strong bases.
Standard chemical-resistant gloves, eye protection and dust control during weighing.
Consult the Safety Data Sheet supplied with the batch before handling.
Regulatory & Documentation Support
This is a starting material rather than a moiety with its own monograph, so a DMF or CEP does not apply to it as a standalone item.
Because it sits at the penultimate stage, however, buyers will scrutinise it more closely than an early intermediate whatever arrives here has fewer steps in which to be purged.
Documentation Supplied
Certificate of Analysis- batch-specific.
Material Safety Data Sheet in GHS format, with destination-language versions on request.
Technical Data Package- manufacturing flow, analytical methods, specification rationale, impurity profile.
GMP Starting Material declaration under ICH Q7 principles, where the GMP grade is ordered.
ICH Q3D elemental impurity statement.
ICH Q3C residual solvent statement.
Certificate of Origin, Non-GMO declaration, BSE/TSE-free and allergen statements.
Site audit access, subject to prior scheduling and confidentiality agreement.
Packaging, MOQ & Logistics
| Parameter | Details |
|---|---|
| Standard Packing | Sealed HDPE containers with double LDPE inner liner, moisture- and light-protected, in outer fibre or HDPE drums |
| Pack Sizes | Available on request |
| Minimum Order Quantity | Available on request |
| Production Lead Time | Available on request |
| Monthly Capacity | Available on request |
| Sampling | Samples available against request |
| Shipping Terms | FOB / CIF / CFR / EXW, as agreed |
| Mode of Transport | Sea and air freight availability available on request, subject to DG classification |
| Transit Protection | Moisture- and light-protected palletised loading |
| Port of Loading | Available on request |
| Export Documentation | Standard commercial documentation |
Why Choose Us as Your Supplier
Batch-to-Batch Consistency
Every batch released against the same analytical protocol, with retained samples held for the declared shelf-life.
Export & Client Support
With 12+ years of B2B pharmaceutical export experience, 500+ global clients and shipments across Asia, Africa, Latin America, the CIS region and the Middle East, our commercial and documentation teams work across time zones.
Frequently Asked Questions
Is this ethanone or ethenone?
Ethanone a ketone. The name is sometimes seen written as “ethenone”, but ethenone means ketene, a completely different and highly reactive species.
The correct name for CAS 221615-75-4 is 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone. Always confirm by CAS number.
How close to the API is this?
One step. Condensing the ketosulphone with a suitable three-carbon reagent closes the second pyridine ring and gives etoricoxib directly.
The methylsulfonyl group, the pyridine methyl and the full carbon skeleton are already in place.
What is the Minimum Order Quantity?
Our minimum order quantity is available on request.
Qualification quantities for a penultimate-stage intermediate are typically larger than for an early building block, and are discussed at enquiry stage.
Request a Quote
Tell us your required quantity, specification and destination, and our team will respond with pricing, lead time and the documentation set for the etoricoxib ketosulphone intermediate (CAS 221615-75-4).